Impact of chronic intranasal oxytocin administration on face expression processing in autistic children: a randomized controlled trial using fMRI

Impact of Oxytocin on Facial Expression Processing in Autistic Children

Study Overview

This study explored how intranasal oxytocin might help autistic children understand facial expressions better. Autism often leads to challenges in social communication, particularly with reading non-verbal cues like facial expressions. Oxytocin could help by making these social signals more noticeable or by lowering anxiety during social interactions.

Methods Used

The research involved 58 autistic children and 38 non-autistic children. We used fMRI scans to observe brain activity while showing different types of faces. In a controlled trial, autistic children received daily doses of oxytocin for four weeks to see how it affected their brain activity related to facial processing.

Key Findings

Overall, there were no major differences in how autistic and non-autistic children processed faces. Similarly, oxytocin treatment did not show significant benefits. However, some initial analyses indicated that oxytocin might reduce brain activity in certain areas related to facial processing, suggesting it could help lessen anxiety during social situations.

Conclusion

The study hints that oxytocin might reduce brain activity related to understanding faces, possibly offering an anxiolytic effect.

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