Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA Phase II, Open-Label Study of Lenalidomide and Dexamethasone Followed by Donor Lymphocyte Infusions in Relapsed Multiple Myeloma Following Upfront Allogeneic Stem Cell Transplant
A Phase II Study on Lenalidomide and Dexamethasone for Relapsed Multiple Myeloma Background Allogeneic stem cell transplant is currently the only potential cure for multiple myeloma (MM), but most patients will relapse. This study aimed to explore the effectiveness and safety of lenalidomide and dexamethasone (Len/Dex) followed by donor lymphocyte infusions (DLIs) in patients who […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseContrast-Enhanced Ultrasound Compared With Hepatobiliary Agent MRI for Differentiation of Focal Nodular Hyperplasia and Hepatic Adenoma: A Prospective Trial
Contrast-Enhanced Ultrasound vs. MRI for Liver Lesions Study Overview This study compares contrast-enhanced ultrasound (CEUS) with MRI for identifying focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA). MRI can be expensive and uncomfortable for patients, so we wanted to see if CEUS could provide similar results. Trial Details Approved by the institutional review board, this […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of the community paramedicine at home (CP@home) program for frequent users of emergency medical services in Ontario: a randomized controlled trial
Effectiveness of the Community Paramedicine at Home (CP@home) Program Overview This study evaluates the CP@home program, which provides home visits by community paramedics to reduce emergency medical services (EMS) calls among frequent users in Ontario. Study Design The research was a 6-month randomized controlled trial, meaning participants were randomly assigned to either the CP@home program […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe effect of a virtual educational intervention based on self-efficacy theory on women’s skills of breast self- examination
The Impact of Virtual Education on Women’s Breast Self-Examination Skills Study Overview This study explored how virtual education affects women’s ability to perform breast self-examinations (BSE), which is vital for early breast cancer detection. The goal was to see if online programs could improve knowledge, self-efficacy, and practical skills related to BSE. Methodology A total […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy and safety of human umbilical cord-derived mesenchymal stem cells versus placebo added to second-line therapy in patients with steroid-refractory acute graft-versus-host disease: a multicentre, randomized, double-blind, phase 2 trial
Efficacy and Safety of Mesenchymal Stem Cells in Treating Steroid-Refractory Acute Graft-Versus-Host Disease Background Many patients with acute graft-versus-host disease (aGVHD) do not respond well to corticosteroids. Mesenchymal stem cells (MSCs) may offer an effective second-line treatment for these patients, but more clinical studies are needed. Study Overview This study involved 78 patients with steroid-refractory […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy and safety of Neurocognitive Adaptive Training for Depression combined with SSRIs for treating cognitive impairment among patients with late-life depression: a 12-week, randomized controlled study
Efficacy and Safety of Neurocognitive Adaptive Training for Depression A 12-Week Study Overview This study explored how Neurocognitive Adaptive Training for Depression (NCAT-D) works with selective serotonin reuptake inhibitors (SSRIs) to help patients with cognitive issues due to late-life depression (LLD). Study Details Conducted from May 5, 2021, to April 21, 2023, at Beijing Anding […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseRandomized Controlled Trial of Cilostazol Addition for In-Stent Restenosis After Carotid Artery Stenting
Randomized Controlled Trial of Cilostazol Addition for In-Stent Restenosis After Carotid Artery Stenting Background Restenosis, or narrowing of the arteries, after carotid artery stenting (CAS) can increase the risk of ischemic stroke. This study looked at whether adding cilostazol to treatment could reduce this risk. Methods In this trial, patients with carotid artery issues scheduled […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of the transtheoretical model-based self-management program on behavioral change in persons with epilepsy: Study protocol for a randomized controlled trial
Study on Self-Management for People with Epilepsy Introduction Self-management tools can make epilepsy treatment more effective and accessible. However, we need more long-term data to prove their benefits. The Transtheoretical Model (TTM) helps tailor self-management to where individuals are in their behavioral change journey. This model aims to address specific needs, reduce information overload, minimize […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Development and feasibility of an mHealth intervention for psychoeducational support of Nigerian women diagnosed with breast cancer undergoing chemotherapy: A pilot randomized controlled trial
Development of a Mobile Health Support Program for Nigerian Women with Breast Cancer Background Breast cancer (BC) is a major health issue worldwide, particularly in Nigeria, where it has high rates of occurrence and death. Chemotherapy, a common treatment, can cause physical and emotional challenges that affect patients’ quality of life. There is a need […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImproving HIV testing, linkage, and retention in care among South African men through U = U messaging: A study protocol for two sequential hybrid type 1 effectiveness-implementation randomized controlled trials
Improving HIV Care for South African Men: Study Overview Background To control the HIV epidemic, it’s vital to increase HIV testing and treatment among people living with HIV (PLHIV). Unfortunately, men, especially in South Africa, are less likely to know their HIV status or begin treatment compared to women. Many men are also at a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Centralized Colorectal Cancer Screening Outreach in Federally Qualified Health Centers: A Randomized Clinical Trial
Centralized Colorectal Cancer Screening Outreach in Health Centers Importance Colorectal cancer (CRC) screening is effective but is not widely used in federally qualified health centers (FQHCs). Objective This study aimed to evaluate a centralized outreach program for CRC screening that included sending fecal immunochemical testing (FIT) kits by mail and providing support for follow-up colonoscopy […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAssessing the National Health, Education, and Air Quality Benefits of the United States Environmental Protection Agency’s School Bus Rebate Program: A Randomized Controlled Trial Design
Evaluating the Benefits of the EPA’s School Bus Rebate Program Introduction In the United States, around 25 million children take school buses to school. While school buses are generally safe, older buses can expose kids to harmful diesel exhaust, affecting their health and school attendance. To promote cleaner buses, the US Environmental Protection Agency (EPA) […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
[(18)F]FDG PET/CT performs better than CT in determining the bone biopsy site : randomized controlled clinical trial
Better Imaging for Bone Biopsies Study Overview A recent clinical trial found that [18F]FDG PET/CT is more effective than CT for locating biopsy sites in patients with suspected bone metastases. This study involved 273 patients treated between January 2020 and March 2021. Key Findings Higher Accuracy: [18F]FDG PET/CT showed an accuracy of 97.08% compared to […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy and safety of prostate radiotherapy in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design
Efficacy and Safety of Prostate Radiotherapy in Metastatic Castration-Sensitive Prostate Cancer Study Overview The PEACE-1 study investigated the effects of adding radiotherapy to standard treatments for men with newly diagnosed metastatic castration-sensitive prostate cancer. This study involved 77 hospitals across Europe and included 1173 male participants. Key Findings Improved Survival: Adding radiotherapy to standard care […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Optimizing parenting and child outcomes following parent-child interaction therapy — toddler: a randomized controlled trial
Optimizing Parenting and Child Outcomes with Parent-Child Interaction Therapy-Toddler Overview Parent-Child Interaction Therapy-Toddler (PCIT-T) is a specialized therapy aimed at helping toddlers aged 12-24 months who exhibit challenging behaviors. Study Design This study used a randomized controlled trial to assess the effectiveness of PCIT-T on toddlers aged 14-24 months with disruptive behaviors. A total of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAdditive effect of glenohumeral joint hydrodilatation applied in addition to suprascapular nerve blockage in patients with adhesive capsulitis
Additive Effect of Shoulder Treatments in Adhesive Capsulitis Study Overview This study explored the effectiveness of shoulder hydrodilatation (HD) combined with suprascapular nerve blockage (SSNB) for patients with adhesive capsulitis (AC). We focused on pain relief, shoulder movement, daily function, and hand strength. Methodology Forty-eight patients diagnosed with AC participated in this study. They were […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDiagnostic Concordance Between Physiotherapist and Emergency Physicians for Patients With a Musculoskeletal Disorder in the Emergency Department
Diagnostic Agreement Between Physiotherapists and Emergency Physicians Study Overview Patients often visit the emergency department (ED) with musculoskeletal disorders. Some hospitals now allow physiotherapists to manage these conditions independently after initial assessment. Understanding how well physiotherapists and emergency physicians agree on diagnoses is important for implementing this care model effectively. Research Findings This study analyzed […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe application of flipped classroom to teaching diabetic retinopathy and glaucoma in ophthalmology undergraduate education: a randomized study
The Study on Flipped Classroom in Ophthalmology Education Overview This study explored how effective the flipped classroom method is for teaching diabetic retinopathy (DR) and glaucoma to medical students. Conducted at Peking Union Medical College, it involved 93 students divided into two groups. Key Findings Group A learned about diabetic retinopathy through a flipped classroom […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEvaluation and randomised controlled trial of home urinalysis testing in patients with SLE at elevated risk for developing lupus nephritis: a study protocol
Evaluation of Home Urinalysis Testing in Patients with SLE Study Overview This study focuses on lupus nephritis (LN), a common issue for patients with systemic lupus erythematosus (SLE). Up to 60% of adult SLE patients may develop LN, which can lead to serious kidney problems. Minority groups often face worse outcomes, making early detection crucial. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Postpartum maternal and infant haematological effects of second-trimester ferric carboxymaltose versus standard-of-care oral iron in Malawi: longitudinal follow-up of a randomised controlled trial
Postpartum Effects of Iron Treatment in Malawi Study Overview Anaemia is a significant issue for mothers and infants in their first year after childbirth, especially in sub-Saharan Africa. This study assessed whether a single dose of intravenous iron, ferric carboxymaltose, is more effective than standard oral iron for treating anaemia during the second trimester of […] ➡️➡️➡️