Comparison of Three Diagnostic Strategies for Pulmonary Embolism
Key Research Findings
Pulmonary embolism (PE) is a challenging condition to diagnose and can be life-threatening when missed. This study aims to compare the effectiveness of three diagnostic strategies: planar ventilation-perfusion scan (V/Q), CT pulmonary angiography (CTPA), and single photon emission CT ventilation-perfusion scan (SPECT V/Q) in diagnosing PE.
Study Design and Objectives
The study will include 3672 patients with suspected PE, divided into three groups using different diagnostic strategies. The primary objective is to determine if the SPECT V/Q diagnostic strategy is as safe and effective as the established strategies in excluding PE. Secondary outcomes include the proportion of patients diagnosed with PE, need for additional tests, incidence of bleeding, and cause of death.
Ethical Considerations
The trial is funded by Brest University Hospital and INVENT, with approval from the Biomedical Research Ethics Committee. All patients will provide informed consent before participating in the trial.
Impact and Future Guidance
The results of this trial will contribute to future clinical practice guidelines and address discrepancies between nuclear medicine and clinical scientific society guidelines in diagnosing PE.
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