Cryoblebbing with 5-fluorouracil versus cryoblebbing with melanocyte keratinocyte transplant procedure or cryoblebbing alone in treatment of stable vitiligo

Study Overview

This study compares three treatment methods for stable vitiligo: cryoblebbing with 5-fluorouracil (5-FU), cryoblebbing with melanocyte-keratinocyte transplant procedure (MKTP), and cryoblebbing alone.

Key Findings

  • Effective Treatments: Both MKTP and 5-FU are effective for vitiligo.
  • Better Results with MKTP: MKTP showed higher repigmentation rates compared to 5-FU.
  • Study Details: Involved 20 patients with stable vitiligo across 128 areas.
  • Repigmentation Rates:
    • MKTP Group: 82.96% average repigmentation
    • 5-FU Group: 44.79% average repigmentation
    • Control Group: 28.23% average repigmentation

Implications for Treatment

MKTP is significantly more effective than 5-FU for treating stable vitiligo. Both treatments showed the reappearance of melanocytes, which are vital for skin pigmentation.

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