Effect of Time-Restricted Eating on IGF1 Levels in Obesity
Study Overview
This study explored how time-restricted eating (TRE) affects levels of IGF1 and its binding proteins in people with obesity. It also looked at how these effects relate to weight loss and body composition changes.
Objective
The main goal was to see how TRE impacts plasma levels of IGF1, IGFBP1, IGFBP2, and IGFBP3, along with insulin sensitivity and inflammatory markers.
Study Design
This was an 8-week randomized controlled trial involving participants with obesity. They were divided into two groups: one group practiced 4 or 6 hours of TRE, while the control group received no dietary guidance.
Participants
The study took place at the University of Illinois at Chicago in 2019, involving 49 participants in total.
Intervention
Participants in the TRE groups fasted daily from 7 p.m. to either 3 p.m. (4 hours) or 1 p.m. (6 hours), followed by regular eating for the rest of the day.
Main Findings
- Participants practicing TRE lost an average of 3.6% of their body weight.
- Significant improvements were noted in insulin levels and other metabolic markers.
- In those who lost more than 3.5% of their weight, IGFBP2 levels increased, while leptin levels decreased.
Conclusions
While TRE did not change IGF1, IGFBP1, or IGFBP3 levels, it did improve insulin sensitivity and other metabolic markers. The study suggests that greater weight loss enhances the benefits of TRE.
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