Exploring the Effect of Exercise versus Metformin on Insulin Resistance amongst Nigerians with Pre-diabetes: A Randomised Controlled Trial

ABSTRACT

Pre-diabetes is a significant risk factor for type 2 diabetes in Nigeria. This study aimed to compare the impact of moderate exercise and metformin interventions on insulin resistance among participants with pre-diabetes.

Using a randomised placebo-controlled design, 54 Nigerians with pre-diabetes were selected and offered metformin, moderate exercise, or placebo treatment for 12 weeks. Both exercise and metformin interventions significantly decreased insulin resistance compared to placebo. However, moderate exercise improved insulin resistance more than metformin.

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Exploring the Effect of Exercise versus Metformin on Insulin Resistance amongst Nigerians with Pre-diabetes: A Randomised Controlled Trial