Background
L-glutamine and linoleic acid (LA) can help reduce skin inflammation, but there haven’t been many studies on using them together because they behave differently.
Aims
This study looked at how glutamine linoleate vesicles (QLAsomes) affect skin irritation by examining their effects on skin proteins related to sensitization, bacterial growth, and their ability to relieve itching.
Methods
Researchers created and tested QLAsomes. They checked how well these vesicles could reduce inflammation and the growth of Staphylococcus aureus bacteria. In a double-blind clinical trial, 24 participants aged 22-63 with sensitive skin used a cream containing 10% QLAsomes on one side of their body and a placebo on the other side, applying it twice daily for two weeks. They measured itchiness in the elbow area using a visual scale and expert assessments. Skin health was evaluated through transepidermal water loss (TEWL), skin redness, and hydration levels.
Results
The QLAsomes, made from L-glutamine and LA, were tiny spherical vesicles (about 164.6 nm in size). They worked better than the individual ingredients in reducing inflammation. For example, the reduction of IL-4 (a protein related to inflammation) improved by over 26%. Another protein that breaks down collagen showed a 32% improvement compared to L-glutamine and a 23% improvement compared to LA. Clinically, the cream reduced itching by 45% compared to baseline and showed a 67% improvement compared to the placebo. Skin assessments indicated better results in redness (12% improvement), TEWL (15% improvement), and hydration (19% improvement), suggesting that QLAsomes strengthen the skin barrier.
Conclusions
QLAsomes inhibited key inflammation-related proteins by up to 32% more than the individual components and improved itching by 67% more than the placebo. These nanovesicles are effective for soothing skin and can be used in both pharmaceutical and cosmetic products.
Opportunities for Clinics and Patients
Based on the trial results, clinics can set measurable goals for using QLAsomes in sensitive skin care. They should:
- Define clear outcomes for skin improvement.
- Select AI tools that meet their specific clinical needs.
- Implement changes gradually, starting with pilot projects and track results effectively.
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