Study on Rezvilutamide vs. Bicalutamide for Prostate Cancer
Overview
The CHART trial (NCT03520478) was a phase 3 study comparing rezvilutamide (REZ) with bicalutamide (BIC) in patients with high-volume metastatic hormone-sensitive prostate cancer (mHSPC) receiving androgen deprivation therapy (ADT). The study found that REZ combined with ADT led to better survival rates and less disease progression compared to BIC-ADT.
Key Findings
- Pain Management: Patients on REZ-ADT experienced a longer duration before their worst pain intensity increased (9.2 months vs. 6.4 months for BIC-ADT).
- Pain Interference: Those receiving REZ-ADT also had a delayed onset of pain interference, lasting 20.2 months compared to 10.2 months for BIC-ADT.
- Overall Functionality: Patients on REZ-ADT showed slower deterioration in their overall health and well-being, with a delay of 12.8 months versus 6.0 months for BIC-ADT.
Conclusion
In summary, REZ-ADT offers significant advantages over BIC-ADT in managing pain and improving patient quality of life for those with high-volume mHSPC.
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