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Prevalence of vitamin D deficiency and the effect of vitamin D3 supplementation on response to anti-tuberculosis therapy in patients with extrapulmonary tuberculosis

Prevalence of Vitamin D Deficiency and the Effect of Vitamin D3 Supplementation on Response to Anti-Tuberculosis Therapy in Patients with Extrapulmonary Tuberculosis

ABSTRACT

We conducted a study to measure serum vitamin D levels in patients with extrapulmonary tuberculosis (EPTB) and to assess the impact of vitamin D3 supplementation on their treatment.

In our study, we found that all EPTB patients had vitamin D deficiency, with significantly lower vitamin D levels compared to healthy controls. Patients who received vitamin D3 supplementation in addition to anti-TB drugs showed improvements in weight gain, serum albumin levels, hemoglobin concentration, and inflammatory markers. Additionally, those with TB pleurisy experienced a higher rate of pleural fluid resolution and shorter treatment duration.

Our findings suggest that vitamin D supplementation is a beneficial adjunctive therapy to anti-TB drugs for EPTB patients.

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