Enhancing Oncolytic Reovirus Therapy in Multiple Myeloma
Key Findings
Proteasome inhibitors (PIs) can significantly boost the effectiveness of reovirus (RV) therapy in treating multiple myeloma (MM), even though PIs are typically known to suppress immune activity.
Study Overview
– Background: RV targets cancer cells but showed limited disease control on its own in MM patients. Combining RV with PIs enhances its therapeutic effects.
– Methods: Various advanced techniques were used, including:
– Electron microscopy and flow cytometry to examine virus infection and immune response.
– T-cell receptor sequencing to analyze immune activity in patients.
Results Highlights
– PIs increase RV replication in monocytes, improving viral delivery to myeloma cells.
– This combination leads to better immune activation and cell killing in MM, regardless of the sensitivity of cancer cells to PIs.
– In a clinical trial with 13 patients, 70% showed positive responses linked to RV activity and T-cell activation.
Conclusions
PIs can enhance the delivery and effectiveness of oncolytic viral therapies in cancer treatments, suggesting a broader application of PIs as support in cancer therapies.
Trial Registration
Registered at clinicaltrials.gov, NCT02101944.
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