Real-World Effectiveness of Antibiotic Strategies for Urinary Tract Infection
Study Overview
A study was conducted to compare the effectiveness of different antibiotic treatments for gram-negative bloodstream infection from a complicated urinary tract infection source.
Methods
- Multicenter observational cohort study
- Comparison of intravenous and oral antibiotic regimens
- Adults treated for Escherichia coli or Klebsiella species infection
Findings
- Oral antibiotics (fluoroquinolones or trimethoprim-sulfamethoxazole) were found to be equally effective as intravenous antibiotics
- High-bioavailability β-lactams were associated with higher recurrence rates
- Suboptimal dosing of high-bioavailability β-lactams was observed in a significant percentage of cases
Conclusion
The study suggests that oral antibiotics can be as effective as intravenous antibiotics for treating urinary tract infections. However, more research is needed to determine the best dosing and duration of treatment to prevent treatment failures.
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Author: John J Veillette