Selenium Supplementation and Gestational Diabetes: A Randomised Controlled Trial
Objective
To evaluate the impact of selenium supplementation on blood glucose levels in women with gestational diabetes mellitus (GDM).
Study Design
Randomised controlled trial conducted at the Department of Internal Medicine, Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkiye, from February to July 2023.
Methodology
Pregnant women’s selenium levels were measured during an oral glucose tolerance test. Those diagnosed with GDM were randomly assigned to two groups: one receiving diet alone and the other receiving diet plus selenium supplementation (200 µg/day) for 4 weeks.
Results
– Pregnant women with GDM had significantly lower selenium levels compared to healthy pregnant women.
– Low selenium levels (<80 ng/ml) were associated with a 2.709-fold higher risk for GDM.
- Fasting blood glucose levels decreased significantly in both groups, with a greater decrease observed in the selenium recipients.
- Selenium recipients also showed lower fasting, 1st and 2nd hour blood glucose levels compared to those who only received diet.
Conclusion
Selenium supplementation had a beneficial impact on blood glucose levels in pregnant women with GDM compared to diet alone.
Key Words
Pregnancy, Pregnancy outcome, Diabetes, Gestational, Dietary supplements, Selenium.
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