Study Highlights
Speech-related temporal parameters (SRTPs) may be sensitive indicators of the efficacy of acetylcholinesterase (AChE) inhibitor therapy in mild Alzheimer’s disease.
Automatic speech recognition in the Speech-Gap Test® revealed improvements in filled pause duration ratio, count ratio, and frequency after 12 and 24 weeks of donepezil treatment.
ADAS-Cog total scores showed slight improvement, with significant improvement observed only in the orientation subtest after 24 weeks of donepezil treatment.
Examining and evaluating speech parameters could play an important role in determining the effects of pharmacological treatment of mild AD.
The study is novel in its application of linguistic parameters as primary outcomes during a drug trial of mild AD in scientific research for the first time.
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