Safety and Efficacy of Multi-Target TKI Combined with Nivolumab in Check-Point Inhibitor-Refractory Patients with Advanced NSCLC Study Overview A study published in BMC Cancer explored the use of anlotinib, a multi-target tyrosine kinase inhibitor, in combination with nivolumab in patients with non-small cell lung cancer (NSCLC) who were resistant to immune checkpoint inhibitors (ICIs). Study…
Study Title Utility, acceptability and applicability of a nucleic acid amplification test in comparison with a syndromic approach in the management of sexually transmitted diseases at Mulago National Referral Hospital in Uganda (ASTRHA): protocol for an open-label, randomised controlled trial Abstract Sexually transmitted diseases (STDs) are common in low-income and middle-income countries (LMICs) and are…
Antiplatelet Therapy After Coronary Artery Bypass Surgery: Five-Year Follow-Up Objective To evaluate the impact of different antiplatelet strategies on patient outcomes following coronary artery bypass grafting. Design Five-year follow-up of the randomized DACAB trial (Different Antiplatelet Therapy Strategy After Coronary Artery Bypass Grafting). Participants 500 patients aged 18-80 years who underwent elective coronary artery bypass…
Hypersensitivity to CGRP as a Predictive Biomarker for Migraine Prevention with Erenumab ABSTRACT Background: This study aimed to assess the predictive value of CGRP-induced migraine attacks for the effectiveness of erenumab treatment in individuals with migraine. Methods: 139 participants with migraine underwent a 20-minute infusion with CGRP, followed by a 24-week treatment period with erenumab.…
Longitudinal Neurofunctional Changes in Medication Overuse Headache Patients After Mindfulness Practice Key Findings Mindfulness practice, when added to standard medication, led to significant reduction in headache frequency and improvement in clinical variables in Chronic Migraine associated with Medication Overuse Headache (CM-MOH) patients. The study revealed that patients practicing mindfulness showed increased functional connectivity in brain…
Efficacy of Green Tea Extract Cream on Improvement of Striae Distensae Introduction Striae distensae is a skin condition that often leads to dermatological consultations, causing itch and burning sensation. Green tea extract, containing polyphenols, amino acids, and minerals, has been suggested to improve stretch marks by reducing inflammation, increasing collagen production, fibroblast proliferation, and skin…
Are Dutch Adults Equally Susceptible to Nudging and Pricing Strategies for Healthier Diets? Practical Findings from the Supreme Nudge Supermarket Trial Supermarket interventions aimed at promoting healthier dietary patterns were studied to see if their effectiveness differed based on psychological and grocery shopping characteristics. Findings from the 12-month trial involving Dutch-speaking adults aged 30-80 years…
Expanding Access to Malaria Diagnosis and Treatment Results from a Cluster Randomized Trial in Madagascar Global progress on malaria control has faced challenges in providing universal access to malaria diagnosis and treatment. Community health workers (CHWs) can improve access to malaria care for children under 5 years (CU5), but are often not permitted to treat…
Preventive Effect of Prenatal Maternal Oral Probiotic Supplementation on Neonatal Jaundice (POPS Study): A Protocol for the Randomised Double-Blind Placebo-Controlled Clinical Trial Abstract Neonatal jaundice is a common and life-threatening health problem in newborns due to an excess of bilirubin. Gut flora may influence bilirubin metabolism, and the infant gut microbiome is often similar to…
Comparative Study on Treatment of Facial Vitiligo Published in Arch Dermatol Res. 2024 Jun 8;316(7):350 Loss and absence of melanocytes due to various factors lead to vitiligo, the most common pigmentation disorder. This study aimed to compare the effectiveness and safety of two treatments for facial vitiligo: excimer light with topical tacrolimus ointment 0.1% and…
Study on the Effect of Multiple Subcisions on Rolling Acne Scars Summary Acne scarring can greatly impact quality of life. Current treatments have limitations, but the subcision technique shows promise for treating rolling acne scars. This study evaluated the effects of multiple subcision treatments compared to no treatment. Methods Five patients with rolling acne scars…
Clinical Trial Results: Long-pulsed nd: YAG Laser Treatment for Nail Psoriasis Overview Nail psoriasis is a challenging condition associated with significant impact on quality of life. This study aimed to evaluate the effectiveness of long-pulsed 1064 nm Nd: YAG laser treatment for fingernail psoriasis using clinical and ultrasonographic assessments. Key Findings After three monthly treatment…
Effects of Intensive Lifestyle Changes on Alzheimer’s Disease Progression Background Research suggests that lifestyle factors may impact Alzheimer’s disease (AD). This study is the first of its kind to investigate whether intensive lifestyle changes can positively influence the progression of mild cognitive impairment (MCI) or early dementia due to AD. Methods This phase 2 trial…
Dapagliflozin Reduces Systemic Inflammation in Patients with Type 2 Diabetes Key Findings: Dapagliflozin, a medication for type 2 diabetes, was found to reduce plasma IL-1B and increase ketone levels, indicating a potential anti-inflammatory effect. The drug also showed no change in PBMC mitochondrial respiration, suggesting a positive impact on inflammation. Practical Solutions and Value: This…
Dose Escalation of Tolinapant in Combination with Chemoradiotherapy for Cervical Cancer Practical Solutions and Value Cervical cancer is a significant health concern, and the standard treatment has limitations. Tolinapant, an IAP antagonist, has shown promise in preclinical studies when combined with cisplatin and radiotherapy. The CRAIN trial aims to assess the safety and effectiveness of…
Study Summary This clinical trial compared the effects of three different intracanal medicaments on postoperative pain and flare-up in patients with posttreatment apical periodontitis (PTAP) undergoing retreatment. Study Participants 120 patients with single-rooted teeth and single-canal PTAP, without spontaneous pain or swellings, were randomly divided into three groups. Interventions Patients received one of the following…
Exploring Relationships with Food After Dietary Intervention in Patients with Colorectal Cancer: A Qualitative Analysis from the PRIMe Trial Abstract Purpose: Patients with cancer often face nutritional challenges and muscle mass loss. This study aimed to understand how participation in the PRIMe trial affected patients’ relationships with food. Methods: Patients with colorectal cancer participated in…
Study Title: Saccharomyces boulardii Combined with Triple Therapy for H. pylori Infection Key Findings: A clinical trial evaluated the effectiveness of combining Saccharomyces boulardii powder with triple therapy for eradicating H. pylori infection in patients with non-ulcer dyspepsia. The study included 144 patients and monitored microbial composition, eradication rates, symptom alleviation, and adverse reactions. Results:…
Impact of Additional Copies of Chromosome 1 Long Arm in Multiple Myeloma Patients Key Findings: Patients with amplification (Amp1q, ≥4 copies of 1q) or gain (Gain1q, 3 copies of 1q) of chromosome 1 long arm (1q) may experience different outcomes and biology compared to those with normal 1q. Presence of Amp1q significantly hampered median progression-free…
OpTAT Trial: Improving Adherence to Oral Anticancer Therapies Summary A pharmacist-led program improved patient adherence to oral anticancer therapies, specifically implementation, among patients with solid cancers. The program included monthly electronic and motivational feedback, educational support, and behavioral components over 12 months. Key Findings Patients in the intervention arm showed consistently higher day-by-day medication implementation…