Effectiveness of personalized rehabilitation in adults suffering from persistent concussion symptoms as compared to usual care: a randomized control trial protocol ABSTRACT Symptoms reported by patients who sustain a concussion are non-specific. Clinicians can better manage patients by performing a standardized clinical exam to identify the underlying causes of symptoms. Aerobic exercise and multimodal rehabilitation…
Yorkshire Lung Screening Trial (YLST) Pathway Navigation Study A Protocol for a Nested Randomised Controlled Trial to Evaluate the Effect of a Pathway Navigation Intervention on Lung Cancer Screening Uptake BMJ Open. 2024 Jul 9;14(7):e084577. doi: 10.1136/bmjopen-2024-084577. Introduction: Lung cancer is a leading cause of cancer death worldwide. The UK National Screening Committee recommended a…
Multidimensional Screening and Intervention Program for Neurocognitive Disorder in Vascular and Multimorbid Outpatients: Study Protocol for a Randomized Clinical Trial Abstract The study aims to develop innovative strategies for individuals with dementia secondary to cerebrovascular or other medical diseases. It emphasizes the importance of physical and cognitive activities in protecting against cognitive decline. Methods The…
Study: Effectiveness of Additional HIV Self-Test Kits as an Incentive to Increase HIV Testing Key Findings: In a study conducted in Western Kenya, offering a second HIV self-test (HIVST) as an incentive within assisted partner services did not significantly impact HIV testing rates or first-time testing. However, those who opted for the second test reported…
Artificial Intelligence-Based Training for Pulmonary Nodule Diagnosis Published in BMC Medical Education, July 2024 Background: The study aimed to assess the effectiveness of an artificial intelligence (AI)-assisted diagnosis system in training junior radiology residents and medical imaging students in detecting and diagnosing pulmonary nodules. Methods: Participants were divided into three groups: two groups of medical…
Prevalence of Vitamin D Deficiency and the Effect of Vitamin D3 Supplementation on Response to Anti-Tuberculosis Therapy in Patients with Extrapulmonary Tuberculosis ABSTRACT We conducted a study to measure serum vitamin D levels in patients with extrapulmonary tuberculosis (EPTB) and to assess the impact of vitamin D3 supplementation on their treatment. In our study, we…
Study: Non-diabetes Status After IGT Diagnosis and Long-Term Risks Background The study aimed to clarify the association between years of non-diabetes status after diagnosis of impaired glucose tolerance (IGT) and the risk of long-term death and cardiovascular outcomes. Methods and Findings 540 individuals with IGT from the Da Qing Diabetes Prevention Study were included in…
Bone Pain and Survival Among Patients With Metastatic, Hormone-Sensitive Prostate Cancer: A Secondary Analysis of the SWOG-1216 Trial Summary: The study aimed to compare survival outcomes among patients with metastatic, hormone-sensitive prostate cancer (MHSPC) based on the presence or absence of baseline bone pain at diagnosis. Methodology: The analysis used patient-level data from the SWOG-1216…
Relaxation Intervention for Diabetic Foot Ulcer Healing Study Overview A pilot study was conducted to assess the feasibility and acceptability of a relaxation intervention for diabetic foot ulcer (DFU) healing. The study compared progressive muscle relaxation with guided imagery (experimental group) to a neutral guided imagery placebo (active control group) and a group that did…
Clinical Trial Results: Interactive Walkway for Fall-Risk Biomarkers in the Elderly Key Findings: Study compared zolpidem and suvorexant in elderly subjects to assess the sensitivity of the Interactive Walkway (IWW) in measuring walking adaptability and fall risk. Results indicated that zolpidem led to decreased performance in walking adaptability, Timed-Up-and-Go test, and body sway, while suvorexant…
Daratumumab in transplant-eligible patients with newly diagnosed multiple myeloma: final analysis of clinically relevant subgroups in GRIFFIN Blood Cancer J. 2024 Jul 8;14(1):107. doi: 10.1038/s41408-024-01088-6. The GRIFFIN study (NCT02874742) investigated daratumumab plus lenalidomide/bortezomib/dexamethasone (D-RVd) in newly diagnosed multiple myeloma (NDMM) patients who are eligible for transplant. The study’s final analysis focused on subgroups, including those…
Possible Protective Effect of Rosuvastatin in Chemotherapy-Induced Cardiotoxicity in HER2 Positive Breast Cancer Patients: A Randomized Controlled Trial Summary Chemotherapy in HER2 positive breast cancer patients can lead to cardiotoxicity. This study investigated the potential protective effect of rosuvastatin against chemotherapy-induced cardiotoxicity. The results showed that rosuvastatin-treated group had significantly lower decline in LVEF, lower…
Duloxetine Effectiveness in Preventing Taxane-Related Neuropathy Key Findings Paclitaxel chemotherapy can lead to long-lasting neuropathy. However, a double-blind randomized trial revealed that duloxetine is a potentially effective medication for preventing both subjective and objective neuropathy in breast cancer patients undergoing paclitaxel treatment. Practical Solutions The study found that daily administration of duloxetine at specific doses…
Frontloading Home Physical Therapy Visits for Patients With Heart Failure: A Multi-center Randomized Controlled Trial Abstract Frontloading home care visits were investigated for their impact on function in persons with heart failure (HF) in a prospective multi-center randomized controlled trial. A total of 82 ambulatory patients participated, with one group receiving frontloaded visits and another…
Frequency of Red Blood Cell Allo-Immunization in Patients Undergoing Blood Transfusion at the Uganda Cancer Institute ABSTRACT There is limited data on red blood cell (RBC) alloimmunization in patients with cancer in sub-Saharan Africa (SSA). We examined the frequency of RBC alloimmunization in transfused patients with cancers in Uganda. METHODS A randomized control trial was…
Study Summary Comparison of Sedation Drugs in Elderly Patients During Gastrointestinal Endoscopy Researchers compared the use of remimazolam besylate and a combination of etomidate and propofol for sedation in elderly patients undergoing gastrointestinal endoscopy. The study aimed to assess the effectiveness and safety of these sedation methods. Key Findings Remimazolam besylate showed comparable safety and…
Phase I Thorough QT/QTc Study of Avacopan in Healthy Participants Study Details A phase I thorough QTc study evaluated avacopan’s effect on cardiac repolarization in healthy participants. The study included both therapeutic and supratherapeutic doses of avacopan, as well as placebo and positive controls. Key Findings The study found that avacopan did not have a…
Digital Technology Revolutionizing Mandibular Fracture Treatment Comparative Analysis of Patient-Specific Plates and Conventional Titanium Plates Objective: To assess the clinical effectiveness of patient-specific plates utilizing digital technology in treating mandibular fractures compared to conventional titanium plates. Materials and Methods: Twenty patients with mandibular fractures were included and randomly assigned to study or control groups. The…
Effects of Discontinuing Antihypertensive Treatment in Nursing Home Residents with Dementia Key Findings Discontinuing antihypertensive treatment in nursing home residents with dementia did not significantly reduce neuropsychiatric symptoms or improve quality of life compared to usual care. Study Details The study involved 205 participants with moderate-to-severe dementia and systolic blood pressure ≤160 mmHg. They were…
Effect of Metformin on Gut Microbiota Imbalance in T2DM Patients and the Value of Probiotic Supplementation ABSTRACT PURPOSE: This study aimed to investigate the impact of metformin on gut microbiota imbalance in patients with type 2 diabetes mellitus (T2DM) and the potential benefits of probiotic supplementation. METHODS: 84 newly diagnosed T2DM patients were randomly assigned…