Dose Escalation of Tolinapant in Combination with Chemoradiotherapy for Cervical Cancer Practical Solutions and Value Cervical cancer is a significant health concern, and the standard treatment has limitations. Tolinapant, an IAP antagonist, has shown promise in preclinical studies when combined with cisplatin and radiotherapy. The CRAIN trial aims to assess the safety and effectiveness of…
Study Summary This clinical trial compared the effects of three different intracanal medicaments on postoperative pain and flare-up in patients with posttreatment apical periodontitis (PTAP) undergoing retreatment. Study Participants 120 patients with single-rooted teeth and single-canal PTAP, without spontaneous pain or swellings, were randomly divided into three groups. Interventions Patients received one of the following…
Exploring Relationships with Food After Dietary Intervention in Patients with Colorectal Cancer: A Qualitative Analysis from the PRIMe Trial Abstract Purpose: Patients with cancer often face nutritional challenges and muscle mass loss. This study aimed to understand how participation in the PRIMe trial affected patients’ relationships with food. Methods: Patients with colorectal cancer participated in…
Study Title: Saccharomyces boulardii Combined with Triple Therapy for H. pylori Infection Key Findings: A clinical trial evaluated the effectiveness of combining Saccharomyces boulardii powder with triple therapy for eradicating H. pylori infection in patients with non-ulcer dyspepsia. The study included 144 patients and monitored microbial composition, eradication rates, symptom alleviation, and adverse reactions. Results:…
Impact of Additional Copies of Chromosome 1 Long Arm in Multiple Myeloma Patients Key Findings: Patients with amplification (Amp1q, ≥4 copies of 1q) or gain (Gain1q, 3 copies of 1q) of chromosome 1 long arm (1q) may experience different outcomes and biology compared to those with normal 1q. Presence of Amp1q significantly hampered median progression-free…
OpTAT Trial: Improving Adherence to Oral Anticancer Therapies Summary A pharmacist-led program improved patient adherence to oral anticancer therapies, specifically implementation, among patients with solid cancers. The program included monthly electronic and motivational feedback, educational support, and behavioral components over 12 months. Key Findings Patients in the intervention arm showed consistently higher day-by-day medication implementation…
Lung Cancer Screening Intervention Trial Key Findings Lung cancer is the deadliest cancer in the US, but early detection through screening improves outcomes. A nonrandomized controlled trial assessed a multifaceted intervention’s impact on identifying and completing recommended lung cancer screening (LCS) services. Study Details The trial involved patients aged 55 to 80 years with a…
Study Results: Subcision with and without Suction for Acne Scars Overview Therapeutic options for acne scars were compared in a randomized control trial. The study aimed to determine the effectiveness of subcision alone versus subcision with suction for treating facial acne scars. Findings The study found that subjects perceived the combination treatment as working more…
Systemic Antibiotics for Pseudomonas Aeruginosa Infection in Outpatients with Lung Diseases: Clinical Trial Results Background The study aimed to determine the impact of dual systemic antibiotic therapy on Pseudomonas aeruginosa in outpatients with COPD, non-CF bronchiectasis, or asthma. Methods The trial was conducted at seven respiratory outpatient clinics in Denmark. Outpatients with pre-existing lung diseases…
Study Protocol: Mental Health Resiliency Intervention for Nurses Background Nurses face high risks of depression, anxiety, burnout, and suicidal ideation, with suicide rates higher than the general population. This trial aims to reduce these risks and improve mental well-being through a combined cognitive-behavioral skills building program and the Modified Interactive Screening Program (mISP). Aims The…
The Effects of Art Therapy and Psychosocial Skills Training on Symptoms and Social Functioning in Patients with Schizophrenia and Their Relatives Objective The study aimed to evaluate and compare the effects of art therapy and psychosocial skills training (PSST) in the treatment of schizophrenia. Methods A total of 15 patients diagnosed with schizophrenia and 12…
Results of Multicenter Study on Dementia Nursing Practice Skills Purpose and Methods The study compared the effectiveness of a person-centered care program and a dementia-type-specific program for nurses in acute-care hospitals across seven locations. The research was conducted from July 2021 to January 2022. Key Findings A total of 158 participants were included, with significant…
Efficacy of Yoga Intervention for Asthma Patients Results of a Randomized Controlled Trial A study was conducted to evaluate the effectiveness of a structured yoga intervention integrated with routine care for asthma patients in improving their pulmonary function and quality of life. The study involved adults aged 18 to 60 with mild to moderate asthma.…
Study on Fosaprepitant for Chemotherapy-Induced Nausea and Vomiting Practical Solutions and Value: Two doses of fosaprepitant were studied for preventing nausea and vomiting caused by three-day cisplatin-based chemotherapy in lung cancer patients. This study aimed to explore the effectiveness and safety of using two doses of fosaprepitant for this purpose. The study involved 204 participants…
Functional Changes in Sleep-Related Arousal After Ketamine Administration Study Details The study examined the effects of ketamine on sleep and mood in individuals with treatment-resistant depression. Research Objectives The aim was to compare sleep metrics between individuals with treatment-resistant major depression (TRD) and healthy volunteers, and to assess whether ketamine normalizes arousal in TRD. Additionally,…
Effects of the “AI-TA” Mobile App on Psychological Symptoms of Young Breast Cancer Survivors Background Young breast cancer survivors often experience psychological challenges, impacting their quality of life. Mobile apps have shown potential as interventions, but their effectiveness varies. There is a lack of evidence on the impact of intelligent app features on addressing psychological…
Service Dogs for Veterans and Military Members With Posttraumatic Stress Disorder: A Nonrandomized Controlled Trial Key Findings: Military members and veterans with posttraumatic stress disorder (PTSD) may benefit from partnering with trained psychiatric service dogs. This study aimed to assess the impact of this intervention on PTSD symptom severity, depression, anxiety, and psychosocial functioning among…
Study Title: The need for and acceptability of a cancer training course for medical and nursing students in Tanzania: a convergent mixed methods study Background The burden of cancer in Africa is increasing, and it is crucial to provide healthcare providers with proper training in cancer screening, prevention, care, and community education. This training can…
Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Non-cardiac Surgery (TRACTION): Protocol for a Phase IV Randomised Controlled Trial Abstract Tranexamic acid (TXA) is a widely available and affordable medication that reduces blood loss and red blood cell (RBC) transfusion in cardiac and orthopaedic surgeries. This trial aims to evaluate whether implementing a…
Results of a Clinical Trial on Riamilovir for COVID-19 Treatment Published in Ter Arkh, June 2024 AIM: To assess the effectiveness and safety of riamilovir in treating COVID-19 in adults. MATERIALS AND METHODS: The study involved 180 adult patients with confirmed COVID-19 who met specific criteria and provided informed consent. RESULTS: The clinical trial confirmed…