Pooled Analysis of NeoCARH and NeoCART Trials: Patient-Reported Outcomes in Early-Stage Breast Cancer Background Neoadjuvant chemotherapy is a standard treatment for early-stage breast cancer (EBC) that is triple-negative or human epidermal growth factor receptor 2 positive (HER2 +). However, there is limited data comparing the impact of anthracycline-based and platinum-based regimens on patients’ health-related quality…
Effectiveness of Topical Hyaluronic Acid in Treating Dry Skin in the Elderly Study Overview Dry skin is a common issue in the elderly, often due to reduced hyaluronic acid (HA) levels. This study aimed to compare the effectiveness of low and high molecular weight HA in moisturizers for treating dry skin in aging individuals. Key…
One Spinal Manipulation Session for Chronic Low Back Pain Key Findings: – Spinal manipulation reduces lumbar pain sensitivity in chronic low back pain patients. – It does not affect postural stability compared to a sham session. – Both the actual and simulated manipulation led to clinically significant decreases in self-reported pain intensity. – A higher…
Effectiveness of Couple Education and Counseling on Cervical Cancer Screening Uptake Key Findings Cervical cancer is a significant global health issue, particularly in developing countries, due to low screening rates and late-stage detection. This study aimed to assess the impact of couple education and counseling on women’s uptake of cervical cancer screening. The intervention involved…
Effect of Adding Diaphragmatic Breathing to Corrective Exercises for Postmenopausal Women with Kyphosis: Clinical Trial Results Overview Age-related thoracic kyphosis can impact posture, diaphragmatic function, and quality of life for postmenopausal women. Methods 40 postmenopausal women with thoracic kyphosis were split into two groups. Group A received corrective exercises for 12 weeks, while Group B…
EFFECT OF LOW-LEVEL DIODE LASER ON DENTIN TOPOGRAPHY AND SYMPTOMATIC NONCARIOUS CERVICAL LESIONS PRIOR TO COMPOSITE RESTORATIONS: A SPLIT-MOUTH RANDOMIZED CONTROLLED TRIAL Summary: This study examined the impact of low-level diode lasers on reducing sensitivity in symptomatic noncarious cervical lesions (NCCLs) before composite restoration. It focused on changes in dentin topography using a scanning electron…
COST-EFFECTIVENESS OF ENOXAPARIN VERSUS ASPIRIN IN PREVENTING VENOUS THROMBOEMBOLISM Key Findings from the CRISTAL Trial The CRISTAL trial compared the costs and benefits of using enoxaparin versus aspirin to prevent symptomatic venous thromboembolism (VTE) after total hip or knee arthroplasty. The study found that: Enoxaparin was more effective in preventing symptomatic VTE within 90 days…
Cost-effectiveness analysis of soft bandage and immediate discharge versus rigid immobilization in children with distal radius torus fractures Summary The study compared the cost-effectiveness of using a soft bandage and immediate discharge versus rigid immobilization in children aged four to 15 years with a torus fracture of the distal radius. The research aimed to evaluate…
Prospective Multicentre Evaluation of FUJIFILM SILVAMP TB LAM Test Key Findings A clinical trial evaluated the diagnostic accuracy of the urine-based lipoarabinomannan assay FUJIFILM SILVAMP TB LAM (FujiLAM) for tuberculosis in people living with HIV across seven high-burden countries. Overall, the FujiLAM demonstrated a sensitivity of 54.4% and specificity of 85.2% against the extended mycobacterial…
Study Title: Sibling-Support for Adolescent Girls (SSAGE) Objective: Preventing Mental Illness among Forcibly Displaced Adolescent Girls Forcibly displaced adolescent girls are at higher risk for mental illness, especially due to gender inequity. The study aims to assess the effectiveness of a whole-family, gender transformative intervention called Sibling Support for Adolescent Girls in Emergencies (SSAGE) in…
Impact of Skills for Change Program on Type 2 Diabetes Management Summary A 12-month trial was conducted in the United Arab Emirates to assess the impact of a culturally adapted lifestyle intervention on adults with type 2 diabetes. The intervention focused on diet and physical activity levels, guided by the social cognitive theory. Key Findings…
Study Title: Incidence of self-reported tuberculosis treatment with community-wide universal testing and treatment for HIV and tuberculosis screening in Zambia and South Africa: A planned analysis of the HPTN 071 (PopART) cluster-randomised trial Key Findings: In a study involving over 1 million individuals, community-wide universal testing and treatment for HIV (UTT) combined with tuberculosis (TB)…
Standard Versus Family-Based Screening, Brief Intervention, and Referral to Treatment for Adolescent Substance Use in Primary Care: Protocol for a Multisite Randomized Effectiveness Trial ABSTRACT Screening, brief intervention, and referral to treatment for adolescents (SBIRT-A) is recommended for detecting and intervening in alcohol and other drug (AOD) use in pediatric primary care. This trial aims…
Comparison of Working Alliance in Blended Cognitive Behavioral Therapy and Treatment as Usual for Depression in Europe Practical Solutions and Value Increasing interest has focused on the working alliance in digital mental health interventions. This study aimed to compare the working alliance scores between blended cognitive behavioral therapy (bCBT) and treatment as usual (TAU) for…
Effect of a diabetes-specific formula in non-diabetic inpatients with stroke: a randomized controlled trial Background/Objectives: In patients with acute stroke, high blood sugar levels have been linked to more severe symptoms and limited recovery. This study aimed to assess the impact of a specialized diabetes-specific liquid nutrition on blood sugar levels, other health problems, and…
Static Palpation Precision Evaluation Study Introduction Clinicians often use manual therapy to treat low back pain by feeling the spine to find the spinous processes. This study aims to assess how well experienced clinicians can consistently locate these spinous processes from S1 to T12 through palpation. The results will be compared to topographical data representing…
Mobile Phone-Based Confidential Social Network Referrals for HIV Testing (CONSORT): Protocol for a Randomized Controlled Trial Background Critical to ending the HIV epidemic is finding undiagnosed individuals and engaging them in care. Using mobile phones in high HIV prevalence areas can help reach social networks for HIV testing and treatment. Objective This study aims to…
Tofacitinib: Effective Treatment for Ulcerative Colitis Highlights of the Study: A pragmatic prospective study assessed tofacitinib’s efficacy for moderate to severe ulcerative colitis (UC). Intestinal ultrasound (IUS) was evaluated as a tool to distinguish responders from non-responders in real-time. Key Findings: • 30 adult patients started tofacitinib; most had left-sided or extensive colitis and had…
Comparison of IASTM and ESWT in Myofascial Pain Syndrome Background/Aim: To compare the effectiveness of instrument-assisted soft tissue mobilization (IASTM) and extracorporeal shock wave therapy (ESWT) in treating myofascial pain syndrome (MPS) and to determine their superiority over conservative treatment (CT). Materials and Methods: 42 female MPS patients were randomly assigned to CT, CT+IASTM, or…
Effects of Mindfulness-Based Cognitive Therapy for Chinese Adults with PTSD Symptoms: Protocol for a Randomised Controlled Trial Abstract Introduction: Mindfulness-based cognitive therapy (MBCT) has shown promise as a potential psychotherapy for post-traumatic stress disorder (PTSD). This trial aims to test the effects of MBCT compared to an active control for individuals with subthreshold PTSD. Method…