Comparison of zuberitamab plus CHOP versus rituximab plus CHOP for the treatment of drug-naive patients diagnosed with CD20-positive diffuse large B-cell lymphoma: a phase 3 trial

Comparison of Zuberitamab Plus CHOP vs. Rituximab Plus CHOP for DLBCL Treatment

Study Overview

This study aimed to compare the effectiveness and safety of zuberitamab plus CHOP against rituximab plus CHOP in patients with untreated CD20-positive diffuse large B-cell lymphoma (DLBCL).

Methods

Patients were randomly assigned to receive six cycles of either zuberitamab or rituximab along with standard CHOP chemotherapy. The main goal was to assess the objective response rate (ORR) after treatment. Secondary goals included complete response rates, duration of response, progression-free survival, and safety evaluations.

Results Summary

Out of 487 patients, 423 completed the assessment. Key findings include:

  • ORR: 83.5% for zuberitamab plus CHOP vs. 81.4% for rituximab plus CHOP.
  • Complete Response Rate: Higher in zuberitamab group (85.7% vs. 77.3%).
  • Survival Rates: Slightly better outcomes in the zuberitamab group for duration of response, progression-free survival, and overall survival.
  • Adverse Events: Similar rates across groups, but infusion-related reactions were more common with zuberitamab.

Conclusions

Zuberitamab plus CHOP is a promising treatment option for DLBCL, showing comparable efficacy to rituximab plus CHOP, with a higher complete response rate and good tolerability.

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