Treatment Outcomes of Pulpotomy vs. Pulpectomy in Vital Primary Molars with Irreversible Pulpitis Background Pulpectomy has been the traditional treatment for vital primary molars with irreversible pulpitis. However, recent advancements suggest that pulpotomy, a more conservative approach, could be effective. This trial aims to compare the effectiveness of pulpotomy versus pulpectomy in managing symptomatic irreversible…
Study Title A study on the effectiveness of low-dose olanzapine in preventing nausea and vomiting during chemotherapy Objective To evaluate the effectiveness of 5 mg olanzapine in preventing chemotherapy-induced nausea and vomiting (CINV) in female patients with gastrointestinal tract tumors undergoing moderately emetogenic chemotherapy (MEC). Methods Patients received either 5 mg olanzapine with palonosetron and…
GLORIA Trial: Combining CXCL12 Inhibition and Radiotherapy in Glioblastoma Key Findings: The GLORIA trial combined radiotherapy with the CXCL12-neutralizing aptamer olaptesed pegol (NOX-A12) in patients with newly-diagnosed glioblastoma. The study found that the treatment was safe and well-tolerated, with no dose-limiting toxicities or treatment-related deaths. Increasing the NOX-A12 dose levels led to higher NOX-A12 plasma…
ASSIST Trial: Impact of Strength Exercise Volume on Insulin Sensitivity in Obese Adults Overview The ASSIST trial aims to investigate the effects of high- and low-volume strength exercise sessions on insulin sensitivity in obese adults, providing valuable insights for personalized exercise prescription. Background Type 2 diabetes mellitus is characterized by impaired insulin action, and acute…
Progesterone for Neurodevelopment in Fetuses With Congenital Heart Defects: A Randomized Clinical Trial ABSTRACT Importance: Children with congenital heart defects (CHD) have seen minimal improvement in neurodevelopmental outcomes over the past 20 years. Objectives: Evaluate the feasibility and tolerability of maternal progesterone therapy and its impact on neurodevelopment in fetuses with CHD. Design, Setting, and…
Phase 1 Study of CK0801 in Treatment of Bone Marrow Failure Syndromes Background An inflammatory bone marrow microenvironment contributes to acquired bone marrow failure syndromes. CK0801, an allogeneic T regulatory (Treg) cell therapy product, can potentially interrupt this continuous loop of inflammation and restore hematopoiesis. Methods In this phase 1 dose-escalation study of CK0801 Treg…
Long-Term Changes of Urinary Exosomal Peptide Levels After Thyroidectomy in Patients with Thyroid Cancer: A Prospective Observational Study ABSTRACT The study aimed to investigate the potential of urine exosomal peptide levels to predict the risk of thyroid cancer recurrence after thyroidectomy. METHODS Patients newly diagnosed with papillary thyroid cancer and who had undergone thyroidectomy were…
Phase 1 Study of MK-5475 for Pulmonary Hypertension in COPD Patients Key Findings: This study assessed the safety and effectiveness of MK-5475 in COPD patients with pulmonary hypertension. The results showed a favorable safety profile and numerical reductions in pulmonary vascular resistance, supporting further development of MK-5475 for PH-COPD treatment. Practical Solutions and Value: Clinical…
Association between insulin sensitivity and lean mass loss during weight loss Objective The study aimed to assess the relationship between insulin sensitivity and changes in total lean mass (LM) and appendicular LM (ALM) during weight loss. Methods Individuals were randomly assigned to either a standard or a moderately reduced carbohydrate diet for 16 weeks. Body…
Comparison of Feedback-Based Learning and Traditional-Based Training for Operating Room Technology Students Background Effective feedback is crucial in clinical education to identify weaknesses and intervene at the right times. This study compared the effects of apprenticeship training using sandwich feedback and traditional methods on the perioperative competence and performance of Operating Room (OR) technology students.…
Comparison of Vitality Test with Sensitivity Tests in Mature and Immature Teeth: Clinical Trial Abstract One of the crucial steps in deciding on tooth treatment is determining the vitality and health status of the pulp. This study compares pulse oximetry (PO), electric pulp test (EPT), and cold test in both mature and immature permanent teeth.…
Internet of Things-Based Home Respiratory Muscle Training for Patients with Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial Abstract Purpose: This study aims to assess the effectiveness of Internet of Things (IoT)-based home respiratory muscle training (RMT) for patients with chronic obstructive pulmonary disease (COPD). Patients and Methods: Seventy-eight patients with COPD were randomly divided…
Effectiveness of a Self-Help Guide for Alcohol Abstinence Key Findings The study aimed to assess the impact of a self-help guide on successful completion of a temporary alcohol abstinence challenge and changes in drinking refusal self-efficacy, behavioral automaticity, craving, and alcohol consumption. After 8 months, all participants experienced a significant decrease in behavioral automaticity, craving,…
Laser Hemorrhoidoplasty vs. Rubber Band Ligation: A Comparison Study Purpose Investigating the clinical efficacy of Laser Hemorrhoidoplasty (LHP) for grade II hemorrhoids as a minimally invasive procedure. Methods 70 patients with grade II hemorrhoids were randomly assigned to receive LHP or Rubber Band Ligation (RBL). Postoperative pain, bleeding, feeling of anal distension, and recurrence rate…
Protocol for CHAMPION study Practical Solutions and Value The CHAMPION study aims to assess the effectiveness of a multi-modal treatment approach for newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC) patients with a limited number of distant metastatic sites. The study focuses on the use of PSMA PET/CT-guided cytoreduction in combination with apalutamide and androgen deprivation…
Comparing the Efficacy of Digital and In-Person Weight Loss Interventions for Patients with Obesity and Glycemic Disorders: Evidence from a Randomized Non-Inferiority Trial Abstract Digital weight loss interventions offer a cost-effective alternative to traditional therapy. This trial aimed to compare the effects of an intensive in-person weight loss intervention program with Vitadio digital therapy for…
Bioavailability of Lutein from Marigold Flowers (Free vs. Ester Forms): A Randomised Cross-Over Study to Assess Serum Response and Visual Contrast Threshold in Adults Published in Nutrients. 2024 May 8;16(10):1415. doi: 10.3390/nu16101415. Lutein (Lut) and zeaxanthin (Zeax) are important for eye health and are found in the blood and retina. They are present in the…
Mindfulness in Pregnancy and Postpartum: Virtually Delivered MBCT Pilot Trial Background During pregnancy and postpartum, vulnerable individuals are at risk for psychological distress. Accessible mental health interventions are needed. Research suggests that Mindfulness-Based Cognitive Therapy (MBCT) can help, but few studies have evaluated it in the perinatal period. We are conducting a pilot trial of…
Effects of FACAM Intervention on Child Development and Parent-Child Interaction Study Overview Published in the International Journal of Environmental Research and Public Health, this study evaluated the impact of the FACAM intervention on vulnerable pregnant women and their children up to two years old. The FACAM intervention provides the services of a health nurse or…
Efficacy of Integrated Risk Score Using Omics-Based Biomarkers for the Prediction of Acute Rejection in Kidney Transplantation: A Randomized Prospective Pilot Study Abstract This study aimed to evaluate the efficacy of integrated risk scoring using omics-based biomarkers in predicting acute rejection in kidney transplant recipients. The study enrolled 40 high-immunologic-risk kidney transplant patients, measuring five…