Palbociclib in Solid Tumor Patients With Genomic Alterations in the cyclinD-cdk4/6-INK4a-Rb Pathway: Results From National Cancer Institute-Children’s Oncology Group Pediatric Molecular Analysis for Therapy Choice Trial Arm I (APEC1621I)
Key Findings:
The study focused on pediatric patients with relapsed solid tumors treated with palbociclib, a cdk4/6 inhibitor.
Practical Solutions:
Using palbociclib at 75 mg/m2 orally daily was well-tolerated in this group of patients.
Value:
No significant objective responses were observed, indicating the need for further research in pediatric cancers.
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