Impact of Intravascular Imaging-Guided Stent Optimization According to Clinical Presentation in Patients Undergoing Complex PCI Practical Solutions and Value Background: The study aimed to determine if intravascular imaging-guided stent optimization has different effects based on the clinical presentation during complex percutaneous coronary intervention (PCI). Methods: Patients with complex coronary artery lesions were randomly assigned to…
The Influence of Diet Therapy and Physical Training on MCP-1 Secretion in Obese Patients with Coronary Heart Disease Key Findings: After a 12-week intervention, participants experienced significant improvements including: 4.0% reduction in body weight 4.2% decrease in waist circumference 5.4% reduction in visceral fat 9.8% decrease in total cholesterol 16.6% decrease in LDL-cholesterol 26% decrease…
Government Direct-to-Consumer Education to Reduce Prescription Opioid Use: A Cluster Randomized Clinical Trial ABSTRACT Importance: Direct-to-consumer education has been effective in reducing chronic sedative use, but its effectiveness for prescription opioids among patients with chronic noncancer pain has not been tested. Objectives: This trial aimed to evaluate the effectiveness of a government-led educational information brochure…
Gastrointestinal symptoms and dietary intake of patients with irritable bowel syndrome following a low FODMAP diet ABSTRACT High FODMAP (fermentable oligo-, di, monosaccharides and polyols) foods have been linked with worsening symptoms of IBS patients. The aim was to compare gastrointestinal symptoms and dietary intake of patients with irritable bowel syndrome following a low FODMAP…
Effects of Athletic Tape on Orofacial Pain and Jaw Movements: Clinical Trial Results Summary Researchers conducted a clinical trial to investigate the effects of athletic tape on orofacial pain and jaw movements in adults with temporomandibular disorder. The study involved 22 participants who were randomly assigned to two groups. Method Participants in Group A had…
Posterior Crossbite Corrections in Early Mixed Dentition: Cost-Effectiveness Analysis Background Unilateral posterior crossbite is a common dental issue in children, and early treatment is recommended for normal growth. The choice of appliances for correcting this condition is important, especially when considering the cost-effectiveness of treatment. Objectives This study aimed to compare the cost-effectiveness of quad…
Efficacy of Esketamine for Prenatal Depression in Mothers Key Results and Practical Considerations Results: A single low dose of esketamine significantly reduced the prevalence of major depressive episodes at 42 days postpartum in mothers with prenatal depression when compared to a placebo. This represents a substantial reduction in postpartum depression risk. Additionally, esketamine led to…
Treatment Outcomes of Pulpotomy vs. Pulpectomy in Vital Primary Molars with Irreversible Pulpitis Background Pulpectomy has been the traditional treatment for vital primary molars with irreversible pulpitis. However, recent advancements suggest that pulpotomy, a more conservative approach, could be effective. This trial aims to compare the effectiveness of pulpotomy versus pulpectomy in managing symptomatic irreversible…
Study Title A study on the effectiveness of low-dose olanzapine in preventing nausea and vomiting during chemotherapy Objective To evaluate the effectiveness of 5 mg olanzapine in preventing chemotherapy-induced nausea and vomiting (CINV) in female patients with gastrointestinal tract tumors undergoing moderately emetogenic chemotherapy (MEC). Methods Patients received either 5 mg olanzapine with palonosetron and…
GLORIA Trial: Combining CXCL12 Inhibition and Radiotherapy in Glioblastoma Key Findings: The GLORIA trial combined radiotherapy with the CXCL12-neutralizing aptamer olaptesed pegol (NOX-A12) in patients with newly-diagnosed glioblastoma. The study found that the treatment was safe and well-tolerated, with no dose-limiting toxicities or treatment-related deaths. Increasing the NOX-A12 dose levels led to higher NOX-A12 plasma…
ASSIST Trial: Impact of Strength Exercise Volume on Insulin Sensitivity in Obese Adults Overview The ASSIST trial aims to investigate the effects of high- and low-volume strength exercise sessions on insulin sensitivity in obese adults, providing valuable insights for personalized exercise prescription. Background Type 2 diabetes mellitus is characterized by impaired insulin action, and acute…
Progesterone for Neurodevelopment in Fetuses With Congenital Heart Defects: A Randomized Clinical Trial ABSTRACT Importance: Children with congenital heart defects (CHD) have seen minimal improvement in neurodevelopmental outcomes over the past 20 years. Objectives: Evaluate the feasibility and tolerability of maternal progesterone therapy and its impact on neurodevelopment in fetuses with CHD. Design, Setting, and…
Phase 1 Study of CK0801 in Treatment of Bone Marrow Failure Syndromes Background An inflammatory bone marrow microenvironment contributes to acquired bone marrow failure syndromes. CK0801, an allogeneic T regulatory (Treg) cell therapy product, can potentially interrupt this continuous loop of inflammation and restore hematopoiesis. Methods In this phase 1 dose-escalation study of CK0801 Treg…
Long-Term Changes of Urinary Exosomal Peptide Levels After Thyroidectomy in Patients with Thyroid Cancer: A Prospective Observational Study ABSTRACT The study aimed to investigate the potential of urine exosomal peptide levels to predict the risk of thyroid cancer recurrence after thyroidectomy. METHODS Patients newly diagnosed with papillary thyroid cancer and who had undergone thyroidectomy were…
Phase 1 Study of MK-5475 for Pulmonary Hypertension in COPD Patients Key Findings: This study assessed the safety and effectiveness of MK-5475 in COPD patients with pulmonary hypertension. The results showed a favorable safety profile and numerical reductions in pulmonary vascular resistance, supporting further development of MK-5475 for PH-COPD treatment. Practical Solutions and Value: Clinical…
Association between insulin sensitivity and lean mass loss during weight loss Objective The study aimed to assess the relationship between insulin sensitivity and changes in total lean mass (LM) and appendicular LM (ALM) during weight loss. Methods Individuals were randomly assigned to either a standard or a moderately reduced carbohydrate diet for 16 weeks. Body…
Comparison of Feedback-Based Learning and Traditional-Based Training for Operating Room Technology Students Background Effective feedback is crucial in clinical education to identify weaknesses and intervene at the right times. This study compared the effects of apprenticeship training using sandwich feedback and traditional methods on the perioperative competence and performance of Operating Room (OR) technology students.…
Comparison of Vitality Test with Sensitivity Tests in Mature and Immature Teeth: Clinical Trial Abstract One of the crucial steps in deciding on tooth treatment is determining the vitality and health status of the pulp. This study compares pulse oximetry (PO), electric pulp test (EPT), and cold test in both mature and immature permanent teeth.…
Internet of Things-Based Home Respiratory Muscle Training for Patients with Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial Abstract Purpose: This study aims to assess the effectiveness of Internet of Things (IoT)-based home respiratory muscle training (RMT) for patients with chronic obstructive pulmonary disease (COPD). Patients and Methods: Seventy-eight patients with COPD were randomly divided…
Effectiveness of a Self-Help Guide for Alcohol Abstinence Key Findings The study aimed to assess the impact of a self-help guide on successful completion of a temporary alcohol abstinence challenge and changes in drinking refusal self-efficacy, behavioral automaticity, craving, and alcohol consumption. After 8 months, all participants experienced a significant decrease in behavioral automaticity, craving,…