Patient consent
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseOnline Disease Management Training for Older Adults With Osteoarthritis: A Randomized Controlled Trial
Online Disease Management Training for Older Adults With Osteoarthritis: A Randomized Controlled Trial Introduction Using online methods in health education is effective for providing individual services to older adults with limited access to health services at low cost, allowing for continuous communication. Methods The study involved 52 older adults diagnosed with osteoarthritis, with 26 in […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA multicenter, prospective, phaseⅡ, single-arm study on the treatment of newly diagnosed multiple myeloma with domestic bortezomib in combination with lenalidomide and dexamethasone
Treating Newly Diagnosed Multiple Myeloma with Innovative Therapy Value of the Study A recent study investigated the effectiveness and safety of a new treatment for newly diagnosed multiple myeloma. The treatment, known as the BLD regimen, combined domestic bortezomib with lenalidomide and dexamethasone. The results showed promising outcomes, with a high overall response rate and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTesting a persuasive health communication intervention (PHCI) for emergency department patients who declined rapid HIV/HCV screening: a randomised controlled trial study protocol
Testing a persuasive health communication intervention (PHCI) for emergency department patients Key Highlights Previous studies have shown that many emergency department (ED) patients in the USA decline HIV or hepatitis C (HCV) testing. We need effective and cost-efficient interventions to increase testing rates, especially for people who inject drugs (PWIDs) who are at higher risk […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale in patients with axial spondyloarthritis: psychometric properties and clinically meaningful thresholds for interpretation
Study on FACIT-Fatigue in Axial Spondyloarthritis Patients Key Findings and Practical Solutions Fatigue is a significant symptom for axial spondyloarthritis (axSpA) patients. The FACIT-Fatigue scale, a 13-item patient-reported outcome, was evaluated for its effectiveness in measuring fatigue severity and impact on daily activities in axSpA patients, including those with non-radiographic axSpA (nr-axSpA) and radiographic axSpA […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA Tele-detection and referral pAthways model for early childhood cariEs control- a protocol for a randomized factorial study: the TRACE study
A Tele-detection and Referral Pathways Model for Early Childhood Caries Control: The TRACE Study Background Early childhood caries (ECC) is a common disease affecting children under 6 years old. It can be reversed in early stages, but often goes undetected. New methods are needed to detect oral diseases early for better control. Methods A randomized […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseRole of Comprehensive Vestibular Rehabilitation Based on Virtual Reality Technology in Residual Symptoms After Canalith Repositioning Procedure
Role of Comprehensive Vestibular Rehabilitation Based on Virtual Reality Technology in Residual Symptoms After Canalith Repositioning Procedure Abstract Background: This study aimed to investigate the effectiveness of comprehensive vestibular rehabilitation using virtual reality (VR) technology in managing residual symptoms following the canalith repositioning procedure. Methods: 124 patients diagnosed with benign paroxysmal positional vertigo and experiencing […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparison ultrasound-guided adductor canal block and surgeon-performed block for pain management after total knee arthroplasty: a prospective randomized controlled study
Comparison of Ultrasound-Guided Adductor Canal Block and Surgeon-Performed Block for Pain Management after Total Knee Arthroplasty: A Prospective Randomized Controlled Study Objective: The study aimed to compare the effectiveness of adductor canal block (ACB) performed by surgeons and anesthesiologists using ultrasound guidance for postoperative pain management after total knee arthroplasty (TKA). Methods: A total of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseOpioid-free anesthesia with esketamine-dexmedetomidine versus opioid-based anesthesia with propofol-remifentanil in shoulder arthroscopy: a randomized controlled trial
Opioid-free Anesthesia vs. Opioid-based Anesthesia in Shoulder Arthroscopy Key Findings: Opioid-free anesthesia (OFA) with esketamine-dexmedetomidine significantly reduced postoperative nausea and vomiting (PONV) compared to opioid-based anesthesia (OBA) with propofol-remifentanil. Patients in the OFA group also experienced shorter post-anesthesia care unit (PACU) stays. Practical Solutions: Implementing OFA with esketamine-dexmedetomidine can help reduce PONV and streamline postoperative […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Efficacy of a buccal and lingual at-home bleaching protocol-A randomized, split-mouth, single-blind controlled trial
Efficacy of At-Home Bleaching on Tooth Surfaces Objective To compare the effectiveness and side effects of at-home tooth bleaching on the outer (buccal) surface only versus both the outer and inner (lingual) surfaces. Materials and Methods Sixty patients with certain tooth color were divided into two groups: one received at-home bleaching on the outer surface […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImpact of a 12-Week Dietary Intervention on Adipose Tissue Metabolic Markers in Overweight Women of Reproductive Age
Impact of a 12-Week Dietary Intervention on Adipose Tissue Metabolic Markers in Overweight Women of Reproductive Age Study Overview The study aimed to assess the effects of a 12-week dietary intervention on metabolic markers of adipose tissue in overweight women of reproductive age. It compared the effectiveness of calorie restriction and low-starch diets, taking into […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial Study Overview Curcumin, derived from turmeric root, has been found to have anti-inflammatory effects, and this study aimed to assess its potential in reducing the risk of atherosclerosis in obese patients with type 2 diabetes. The […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effect of rosuvastatin versus atorvastatin on new-onset diabetes mellitus in patients treated with high-intensity statin therapy for coronary artery disease: a post-hoc analysis from the LODESTAR randomized clinical trial
Effect of Rosuvastatin versus Atorvastatin on New-Onset Diabetes Mellitus in Patients Treated with High-Intensity Statin Therapy for Coronary Artery Disease Key Findings: Among patients with coronary artery disease (CAD) receiving high-intensity statin therapy, the incidence of new-onset diabetes mellitus (NODM) was not significantly different between those treated with rosuvastatin and atorvastatin. However, a notable drug […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImpact of fine needle aspiration cytology strategy implemented at the microscopy center level for diagnosis of tuberculous lymphadenitis
Impact of Fine Needle Aspiration Cytology Strategy for Diagnosis of Tuberculous Lymphadenitis Introduction In India, tuberculosis (TB) is a significant concern, particularly in individuals with HIV/AIDS. Extrapulmonary TB (EPTB) accounts for about 50% of TB cases, with tuberculous lymphadenitis being the most common form, representing around 35% of EPTB cases. Fine needle aspiration cytology (FNAC) […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePrimary premature ejaculation of kidney deficiency and liver stagnation treated with warm acupuncture of large-quantity moxibustion: a randomized controlled trial
Primary Premature Ejaculation Treatment Study Exploring Warm Acupuncture with Large-Quantity Moxibustion Objective: To investigate the clinical impact of warm acupuncture with large-quantity moxibustion on primary premature ejaculation (kidney deficiency and liver stagnation). Methods: 240 patients were randomly assigned to a warm acupuncture group, an acupuncture group, or a western medication group. The warm acupuncture group […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePricking-cupping combined with auricular thumbtack needle for postherpetic neuralgia of qi stagnation and blood stasis on chest and waist: a randomized controlled trial
Practical Solutions for Postherpetic Neuralgia Treatment Combining Traditional Techniques with Modern Medicine Pricking-cupping combined with auricular thumbtack needle treatment has shown promising results for postherpetic neuralgia (PHN) of qi stagnation and blood stasis on chest and waist. This randomized controlled trial compared this approach with oral pregabalin capsule treatment. Key Findings: Patients receiving pricking-cupping combined […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effect of utilizing either a self-reported questionnaire or administrative data alone or in combination on the findings of a randomized controlled trial of the long-term effects of antenatal corticosteroids
Effect of Utilizing Different Data Sources on Clinical Trial Findings Key Findings: A study investigated the impact of using self-reported questionnaires, administrative data, or a combination of both on the outcomes of a long-term clinical trial. Results showed that utilizing different data sources had no significant impact on the study findings compared to when outcomes […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Empowering mind-body wellness: effect of bundling seated exercises and psychoeducational rehabilitation using the teach-back approach on fatigue and coping of women postmastectomy
Empowering mind-body wellness: effect of bundling seated exercises and psychoeducational rehabilitation using the teach-back approach on fatigue and coping of women postmastectomy ABSTRACT Being diagnosed with Breast Cancer (BC) can cause significant fatigue and disrupt a patient’s life. Our study aimed to investigate the impact of combining seated exercises and psychoeducational rehabilitation using the teach-back […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseInflammatory markers and noncoding-RNAs responses to low and high compressions of HIIT with or without berberine supplementation in middle-aged men with prediabetes
Inflammatory Markers and Noncoding-RNAs Responses to HIIT and Berberine Supplementation in Prediabetic Men Study Overview This study compared the effects of two different models of high-intensity interval training (HIIT) with or without berberine supplementation on inflammatory markers and insulin resistance in middle-aged men with prediabetes and overweight or obesity. Key Findings All exercise interventions led […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSurgical advantage of modified labial salivary gland biopsy using chalazion forceps: a prospective randomized controlled study
Surgical Advantage of Modified Labial Salivary Gland Biopsy Using Chalazion Forceps: A Prospective Randomized Controlled Study Key Findings: Modified labial salivary gland biopsy (LSGB) using chalazion forceps showed significant advantages over traditional LSGB, including: Smaller incision Shorter operative time Less intraoperative bleeding Lower 24-hour post-surgery pain score Better incision healing at 7 days after surgery […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The effect of Chinese herbal medicine on male factor infertility: study protocol for a randomized controlled trial
The Effect of Chinese Herbal Medicine on Male Factor Infertility: Study Protocol for a Randomized Controlled Trial Background The global prevalence of infertility is 9%, with male factors potentially accounting for 40% to 60% of cases. Conventional treatments can be ineffective, invasive, costly, and linked to adverse effects and high risks. Previous studies have shown […] ➡️➡️➡️