Effectiveness of a Self-Help Guide for Alcohol Abstinence Key Findings The study aimed to assess the impact of a self-help guide on successful completion of a temporary alcohol abstinence challenge and changes in drinking refusal self-efficacy, behavioral automaticity, craving, and alcohol consumption. After 8 months, all participants experienced a significant decrease in behavioral automaticity, craving,…
Laser Hemorrhoidoplasty vs. Rubber Band Ligation: A Comparison Study Purpose Investigating the clinical efficacy of Laser Hemorrhoidoplasty (LHP) for grade II hemorrhoids as a minimally invasive procedure. Methods 70 patients with grade II hemorrhoids were randomly assigned to receive LHP or Rubber Band Ligation (RBL). Postoperative pain, bleeding, feeling of anal distension, and recurrence rate…
Protocol for CHAMPION study Practical Solutions and Value The CHAMPION study aims to assess the effectiveness of a multi-modal treatment approach for newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC) patients with a limited number of distant metastatic sites. The study focuses on the use of PSMA PET/CT-guided cytoreduction in combination with apalutamide and androgen deprivation…
Comparing the Efficacy of Digital and In-Person Weight Loss Interventions for Patients with Obesity and Glycemic Disorders: Evidence from a Randomized Non-Inferiority Trial Abstract Digital weight loss interventions offer a cost-effective alternative to traditional therapy. This trial aimed to compare the effects of an intensive in-person weight loss intervention program with Vitadio digital therapy for…
Bioavailability of Lutein from Marigold Flowers (Free vs. Ester Forms): A Randomised Cross-Over Study to Assess Serum Response and Visual Contrast Threshold in Adults Published in Nutrients. 2024 May 8;16(10):1415. doi: 10.3390/nu16101415. Lutein (Lut) and zeaxanthin (Zeax) are important for eye health and are found in the blood and retina. They are present in the…
Mindfulness in Pregnancy and Postpartum: Virtually Delivered MBCT Pilot Trial Background During pregnancy and postpartum, vulnerable individuals are at risk for psychological distress. Accessible mental health interventions are needed. Research suggests that Mindfulness-Based Cognitive Therapy (MBCT) can help, but few studies have evaluated it in the perinatal period. We are conducting a pilot trial of…
Effects of FACAM Intervention on Child Development and Parent-Child Interaction Study Overview Published in the International Journal of Environmental Research and Public Health, this study evaluated the impact of the FACAM intervention on vulnerable pregnant women and their children up to two years old. The FACAM intervention provides the services of a health nurse or…
Efficacy of Integrated Risk Score Using Omics-Based Biomarkers for the Prediction of Acute Rejection in Kidney Transplantation: A Randomized Prospective Pilot Study Abstract This study aimed to evaluate the efficacy of integrated risk scoring using omics-based biomarkers in predicting acute rejection in kidney transplant recipients. The study enrolled 40 high-immunologic-risk kidney transplant patients, measuring five…
Effects of Esketamine on Postoperative Fatigue Syndrome in Patients after Laparoscopic Resection of Gastric Carcinoma: A Randomized Controlled Trial Background Despite various postoperative management strategies, postoperative fatigue syndrome (POFS) remains common in patients undergoing laparoscopic radical gastrectomy. Esketamine, an N-methyl-D-aspartic acid receptor antagonist, has shown effectiveness in improving sleep quality and reducing postoperative pain. However,…
Integration of Case-Based Learning and Three-Dimensional Printing for Tetralogy of Fallot Instruction Key Findings: Combining case-based learning (CBL) with 3D-printed models results in improved performance in post-class examinations, particularly in pathological anatomy and TOF imaging data analysis. Students in the CBL-3DP group reported enhanced satisfaction with teaching mode, improved diagnostic skills, bolstered self-assurance in managing…
Detection of Scapholunate Interosseous Ligament Injury Key Findings Comparison of injury detection methods for scapholunate ligament injuries 4DCT imaging showed utility for diagnosing ligamentous wrist injury CT-derived biomarkers, arthrokinematics, were used to assess injury status Significantly greater interosseous proximities in injured versus uninjured wrists Improved early diagnosis and confirmation of scapholunate ligament injury Clinical Trial…
Evaluation of Yukwool-tang for Major Depressive Disorder in Women Summary This study aimed to evaluate the effectiveness and safety of Yukwool-tang (YWT) for Major Depressive Disorder (MDD) in women. Method 72 MDD patients were randomly assigned to the YWT or placebo group and received treatment for 8 weeks, with various assessments conducted throughout the trial.…
Effects of Speculum Lubrication on Cervical Smears for Cervical Cancer Screening: A Double Blind Randomized Clinical Trial Background Speculum lubrication may reduce pain during Pap-smear collection, potentially increasing uptake of cervical cancer screening. However, concerns exist about its impact on cytological results. Aim To compare the adequacy of cervical cytology smears and pain scores of…
Examining the Effects of a Brief, Fully Self-Guided Mindfulness Ecological Momentary Intervention on Empathy and Theory-of-Mind for Generalized Anxiety Disorder: Randomized Controlled Trial ABSTRACT The study investigated the effectiveness of a 14-day, self-guided mindfulness intervention on empathy and theory-of-mind in adults with generalized anxiety disorder (GAD). Key Findings The mindfulness intervention showed improvements in specific…
Exploring Therapeutic Mechanisms of Chuan Huang Fang-II in the Treatment of Acute Kidney Injury on Chronic Kidney Disease Patients Study Information Journal: Ren Fail. 2024 Dec;46(1):2356021 DOI: 10.1080/0886022X.2024.2356021 Date: Epub 2024 May 24 Objective This study evaluates the effectiveness and safety of CHF-II combined with RG for treating AKI on CKD (A on C) and…
Evaluating Palliative Care Case Conferences in Primary Care for Patients with Advanced Non-Malignant Chronic Conditions: KOPAL Trial Background Patients with congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), and dementia often do not receive specialist palliative home care (SPHC) despite the complexity of their conditions. Collaboration between general practitioners (GPs) and SPHC teams is…
A Comparison of Pain Relief Methods after Laparoscopy Objective To compare the effectiveness of using bupivacaine alone versus bupivacaine combined with dexmedetomidine for pain relief after laparoscopy procedures. Method A study conducted at a cancer hospital in Lahore, Pakistan, involving adult patients undergoing laparoscopy. Patients were divided into two groups, with Group A receiving bupivacaine…
Comparison of Propolis and Gluma Desensitizer for Dentin Hypersensitivity Key Findings: Propolis and Gluma desensitizers were compared in a randomized controlled trial for managing dentin hypersensitivity. Immediate reduction in dentin hypersensitivity was observed with both agents. After one month, Gluma was found to be more effective than propolis. Practical Solutions and Value: Clinical trials are…
Early Diagnosis of Melanoma: Impact of Smartphone Photo Transmission on Dermatological Consultation Time Background: Difficulty in obtaining timely dermatological consultation hinders early melanoma diagnosis. Optimizing patient care pathways is crucial to improve patient outcomes. Methods: A randomized controlled study involved 51 French GPs and 250 patients referred for suspected melanoma lesions. GPs were randomized to…
Preventive Efficacy of Silver Diamine Fluoride and CPP-ACP Fluoride Varnish on Molars Affected by Molar Incisor Hypomineralization in Children Overview This study compared the effectiveness of silver diamine fluoride (SDF) and Casein Phosphopeptide-Amorphous Calcium Phosphate fluoride Varnish (CPP-ACPFV) in preventing caries, enamel breakdown, and sensitivity in children with molar incisor hypomineralization (MIH). Key Findings The…