Clinical Trial Results: Transvaginal Natural Orifice Transluminal Endoscopic Surgery for Ovarian Cysts Key Findings The study aimed to assess the safety and feasibility of using transvaginal natural orifice transluminal endoscopic surgery (vNOTES) for managing ovarian cysts. The results showed that vNOTES was not inferior to conventional laparoscopy (CL) in terms of adnexectomy or ovarian cystectomy.…
Participants’ Perspectives on Weight Loss Intervention Trial Before Colorectal Cancer Surgery Key Findings Patients with excess weight awaiting colorectal cancer surgery were motivated by the offer of structured weight loss support that could potentially improve their surgical outcomes. However, concerns about the potential unpalatability of the intervention diet and side effects were also expressed. Positive…
Maintenance Therapy with Anlotinib for Advanced Non-Small-Cell Lung Cancer Key Findings Maintenance therapy with anlotinib after platinum-based chemotherapy showed a median progression-free survival of 5.95 months and a median overall survival of 18.60 months in patients with advanced non-small cell lung cancer. Results Out of 23 patients, 19 had stable disease, 1 had a partial…
Effectiveness of HIV Self-Testing in Assisted Partner Services (APS-HIVST Study) Practical Solutions and Value Assisted partner services (APS) is a successful strategy for increasing HIV testing, new diagnoses, and linkage to care among partners of people living with HIV (PLWH). However, it can be resource intensive. This study aimed to assess the effectiveness of offering…
Bronchoscopy with and without Needle-Based Confocal Laser Endomicroscopy for Peripheral Lung Nodule Diagnosis: Protocol for a Multicentre Randomised Controlled Trial (CLEVER Trial) Introduction Despite technological advances, bronchoscopic peripheral lung nodule analysis still faces limitations due to frequent mispositioning. Needle-based confocal laser endomicroscopy (nCLE) provides real-time microscopic feedback on needle positioning, potentially improving sampling location and…
HAP-FAST Feasibility Study Key Points: • Evaluating the clinical impact of low-dose CT scans and rapid molecular sputum analysis for suspected non-ventilator-associated hospital-acquired pneumonia (nv-HAP). • Incorporating a pilot trial, qualitative study, costing analysis, and immune-pathophysiology investigation. • Participants recruited from four acute hospitals in the Northwest of the UK. • Assessing trial processes, outcome…
Comparing Autologous Blood, Corticosteroid, and Combined Injection for Lateral Epicondylitis Treatment Background Lateral epicondylitis is a common forearm condition, and this study compared the effectiveness of autologous blood (AB) injection, corticosteroid (CS) injection, and a combined injection of both in treating the condition. Materials and Methods 120 patients were divided into three groups for different…
Predictive Values of Pre-treatment Brain Age Models to rTMS Effects in Neurocognitive Disorder with Depression Introduction Developing personalized repetitive transcranial magnetic stimulation (rTMS) faces challenges due to high inter-individual treatment response variations. Brain morphometry may contribute to these variations. This study aimed to determine if an individual’s brain morphometry could predict rTMS responders and remitters.…
Study Title: A mixed methods process evaluation of HIV prevention services in rural South Africa Background Combination prevention interventions integrated with community-based support have shown to benefit adolescent and young people’s sexual and reproductive health. The trial aimed to evaluate the delivery of HIV prevention and care among young people through integrated HIV and sexual…
Comparison of Ultrasound Probes for Lung Ultrasound in Neonates Key Findings: Study compared different ultrasound probes for lung ultrasound in neonates. Lower NPLUS scores with echo and microconvex probes compared to linear probe. Strong correlation between pulse oximetric saturation/fraction of inspired oxygen ratio and NPLUS score using microconvex probe. Practical Solutions and Value: Results confirm…
Determining the optimal frequency of SARS-CoV-2 regular asymptomatic testing: A randomized feasibility trial in a home care setting Background The SARS-CoV-2 pandemic has posed challenges for caregivers in home care settings, as they can transmit the virus to their high-risk relatives. Regular asymptomatic testing of caregivers may help reduce transmission, but the best testing frequency…
Web-Based Cognitive Behavioral Treatment for Bulimia Nervosa: A Randomized Clinical Trial Practical Solutions and Value Despite effective treatments for bulimia nervosa (BN), many individuals do not receive evidence-based therapies. Integrating digital interventions into routine care can reach more patients and reduce the clinical burden of BN. A web-based cognitive behavioral self-help intervention was evaluated for…
Prediction of Long-Term Treatment Outcomes for Diabetic Macular Edema Using a Generative Adversarial Network ABSTRACT The study aimed to use generative adversarial networks (GANs) to analyze optical coherence tomography (OCT) images for predicting diabetic macular edema outcomes after long-term treatment. METHODS Diabetic macular edema (DME) eyes (n = 327) from a randomized controlled trial underwent…
Can Biomarkers Predict Ventilator-associated Pneumonia in Patients After Cardiac Arrest? Summary Ventilator-associated pneumonia (VAP) is a common complication after cardiac arrest, but diagnosing it accurately remains a challenge. This study aimed to evaluate the usefulness of biomarkers in diagnosing VAP in post-cardiac arrest patients. Study Design This study was part of the ANTHARTIC trial, a…
Impact of Coenzyme Q10 as Adjuvant Therapy to Letrozole Spermiogram Results and Sex Hormone Levels in Iraqi Men with Infertility Background: Infertility affects about 15% of reproductive-age couples globally. The clinical trial aimed to assess the effects of adding Coenzyme Q10 (CoQ10) to letrozole on the spermiogram and sex hormone levels in men with idiopathic…
Peer2Me: A Peer-Supported Program for AYA Cancer Patients Study Protocol of a Randomised Trial Using a Comprehensive Cohort Design Background: Young adult cancer patients often experience psychological distress and unmet support needs. The Peer2Me intervention aims to provide peer support to AYA cancer patients to enhance self-efficacy and coping with the disease. Methods: The study…
Effect of Cuff Inflation with Lidocaine, Saline, and Air on Tracheal Tube Cuff Pressure during Laparoscopic Resection of Colorectal Neoplasms: A Randomized Clinical Trial BMC Anesthesiol. 2024 Jul 1;24(1):216. doi: 10.1186/s12871-024-02606-6. Background: This trial aimed to determine if inflating tracheal tube cuffs with normal saline or lidocaine can prevent an increase in cuff pressure and…
Evaluating Subthreshold Micropulse Laser Combined with Ranibizumab for Diabetic Macular Edema Study Overview A study was conducted to assess the effectiveness and safety of using subthreshold micropulse laser (SMPL) in combination with ranibizumab for treating diabetic macular edema (DME). Patients were randomly assigned to receive either ranibizumab monotherapy or the combination therapy. Key Findings Both…
Feasibility of Cardiac Brief Intervention for ST-elevation Myocardial Infarction Patients Key Points: Patients often experience emotional distress and misconceptions after a heart attack. This study aims to assess the feasibility of providing a nurse-led, 20-minute emotional and educational support discussion, along with a memory-aid leaflet, to patients before discharge from the hospital. Participants will be…
Efficacy, Safety, Satisfaction, Adherence to Treatment With Nano-Formulated Cysteamine Tranexamic Acid Cream to Treat Melasma Key Findings An innovative cream combining cysteamine and tranexamic acid (TXA) showed significant improvement in treating subjects with epidermal melasma. Results Continuous improvement in melasma was observed, with modified Melasma Area and Severity Index (mMASI) scores improving by 40%, 57%,…