Textured Insoles Feasibility Trial for Children with Motor Coordination Issues Summary Textured insoles may improve balance measures in children with motor coordination issues, but do not show significant impact on endurance measures. The trial aimed to assess the feasibility of conducting a randomised controlled trial for children with motor coordination issues and to evaluate the…
Re-evaluating Insomnia Severity Index in Clinical Trials Key Findings and Practical Solutions Background: The Insomnia Severity Index (ISI) is commonly used to assess insomnia severity, but different research findings have led to variations in defining meaningful within-individual change (MWIC) for treatment response. Methods: We analyzed data from two large clinical trials of lemborexant to improve…
Comparing Performance of Primary Care Clinicians in the Interpretation of SPIROmetry with or without Artificial Intelligence Decision Support Software (SPIRO-AID): A Protocol for a Randomised Controlled Trial ABSTRACT Spirometry, a lung function test, is crucial for diagnosing and monitoring chronic lung disease. However, its interpretation in primary care varies in quality and accuracy. This study…
Predictors of long-term progression-free survival in ovarian cancer patients treated with niraparib Key Findings In a study on advanced ovarian cancer patients receiving niraparib maintenance therapy, certain factors were found to be associated with long-term progression-free survival (≥2 years). Practical Implications The study identified that patients with BRCA1/2 mutation/homologous recombination-deficiency status, FIGO stage III, and…
Exploring Relations Between Unique Patient Characteristics and Virtual Reality Immersion Level on Anxiety and Pain in Patients Undergoing Venipuncture: Secondary Analysis of a Randomized Control Trial ABSTRACT Virtual reality (VR) has been widely studied as a digital tool for managing acute pain and anxiety in pediatric patients during medical procedures. This study investigates how specific…
Exercise-Induced Oxygen Desaturation and Arterial Stiffness in COPD Patients Study Overview This study aimed to investigate the impact of exercise-induced oxygen desaturation (EID) on arterial stiffness in individuals with COPD. Patients underwent the 6-minute walk test (6-MWT) with continuous monitoring of blood oxygen saturation (SpO2) to assess the acute effects of exercise on arterial stiffness.…
Study Title: Calcium Dibutyryl Adenosine Cyclophosphate Enhances the Effect of Metoprolol in Treating Older Adults With Heart Failure Combined With Arrhythmia Objective: To investigate the effectiveness and safety of combining calcium dibutyryl adenosine cyclophosphate (dbcAMP-Ca) with metoprolol in treating older adults with heart failure and arrhythmia. Methods: – 102 elderly patients were enrolled and randomly…
Low Pressure versus Standard Pressure Pneumoperitoneum in Laparoscopic Appendectomy: A Randomized Controlled Trial Key Findings The use of low pressure pneumoperitoneum did not reduce the incidence of abdominal pain in patients who had laparoscopic appendectomy. Patients with acute appendicitis can be treated with either low or normal pressure pneumoperitoneum depending on the experience of the…
Efficacy and Safety of Combination Therapy for Schistosomiasis in Kenyan Children Introduction Reliance on praziquantel for treating schistosomiasis may lead to drug resistance. We evaluated the efficacy and safety of combining praziquantel with artesunate plus sulfalene-pyrimethamine in Kenyan children with schistosomiasis. Methods 426 children aged 7-15 were randomly assigned to receive praziquantel alone, artesunate plus…
Empagliflozin Reduces Ventricular Arrhythmias in Type 2 Diabetes Patients Study Overview Sodium-glucose cotransporter 2 (SGLT2) inhibitors like empagliflozin have shown benefits in reducing heart failure and cardiovascular death in type 2 diabetes patients. This study aimed to investigate the effects of empagliflozin on ventricular arrhythmias in patients with type 2 diabetes who were treated with…
Exploring the Impact of Link Workers on Multimorbidity in Deprived Communities Overview An exploratory trial was conducted to assess the feasibility, impact, and cost effectiveness of using link workers to connect individuals with multiple health conditions to non-clinical supports in deprived urban communities. The study aimed to evaluate the benefits of this approach on health…
Anti-dsDNA IgE: a Potential Non-Invasive Test for Prediction of Lupus Nephritis Relapse RMD Open. 2024 Jun 28;10(2):e004255. doi: 10.1136/rmdopen-2024-004255. Objectives: The WIN-IgE study aims to assess the value of serum anti-dsDNA IgE autoantibodies as a biomarker for predicting relapse in severe lupus nephritis (LN) to guide the discontinuation or continuation of maintenance immunosuppressive therapy (MIST).…
Hydromorphone combined with ropivacaine for erector spinae plane block in patients undergoing modified radical mastectomy: A prospective randomized controlled trial Medicine (Baltimore). 2024 Jun 28;103(26):e38758. doi: 10.1097/MD.0000000000038758. Background: Combining hydromorphone with ropivacaine in ultrasound-guided erector spinae plane blocks enhances postoperative pain relief and reduces interleukin-6 expression in breast surgery patients. Methods: Breast cancer patients undergoing…
Prospective, Randomised Clinical Trial on Silicone Intubarium Necessity in Endonasal-Endoscopic Dacryocystorhinostomy (EN-DCR) Background This study evaluates the impact of using a silicone stent tube (SST) on the success of EN-DCR for treating primary acquired nasolacrimal duct obstruction. Methods Patients were randomly assigned to receive EN-DCR with or without SST intubation. The surgery was performed using…
Clinical Trial: Efficacy of Sivelestat in Treating Sepsis Patients with ARDS and SCM Background Researchers assessed the effectiveness of sivelestat, a neutrophil elastase inhibitor, in treating sepsis-induced acute respiratory distress syndrome (ARDS) and septic cardiomyopathy (SCM). Methods A randomized trial was conducted on patients diagnosed with sepsis-induced ARDS and SCM at Wuhan Union Hospital. The…
Developing a Fit-for-Purpose Composite Symptom Score for Malignant Pleural Mesothelioma Clinical Trials Key Practical Solutions and Value We developed a composite symptom score (CSS) to measure disease-related symptom burden in patients with malignant pleural mesothelioma (MPM). The CSS, derived from the MD Anderson Symptom Inventory for MPM, includes 5 symptoms: pain, fatigue, shortness of breath,…
Clinical Trial Results: Afatinib in Metastatic Esophageal Squamous Cell Carcinoma Key Findings: Preclinical data demonstrated promising antitumor activity of afatinib in EGFR-overexpressing ESCC. Phase II trial showed a confirmed objective response rate (ORR) of 39% and a median overall survival of 7.8 months in pretreated metastatic ESCC patients with EGFR overexpression. Transcriptome analysis revealed a…
Local Radiotherapy and Measurable Residual Disease-Driven Immunotherapy in Early-Stage Follicular Lymphoma (FIL MIRO) Trial: Final Results Practical Solutions and Value Highlights: Local radiotherapy and anti-CD20 monoclonal antibody (mAb) treatment were evaluated using a measurable residual disease (MRD)-driven approach. Patients with early-stage follicular lymphoma were initially treated with radiotherapy, and those still MRD-positive received anti-CD20 mAb…
Phase II Study of Ulixertinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Alterations: APEC1621J of the National Cancer Institute-Children’s Oncology Group Pediatric MATCH Trial Summary The National Cancer Institute-Children’s Oncology Group (NCI-COG) Pediatric MATCH trial tested ulixertinib, a targeted therapy, in patients aged 1-21 with refractory malignancies harboring genetic…
Effectiveness of Eccentric Load in Upper Limb Injury Rehabilitation Practical Solutions and Value The study aimed to assess the effectiveness of therapeutic exercises with eccentric muscle loads in rehabilitating patients with upper limb injuries. This is particularly relevant for athletes, elderly individuals, and those with an active lifestyle. Patients were divided into two groups: one…