Abbreviated or Standard Antiplatelet Therapy After PCI in Diabetic Patients at High Bleeding Risk
Study Overview
This study examines the effects of abbreviated antiplatelet therapy (APT) compared to standard APT in patients with high bleeding risk (HBR) who have diabetes mellitus (DM). The goal is to find out if a shorter treatment duration can reduce bleeding without increasing heart-related issues.
Key Findings
- Background: Abbreviated APT can lower bleeding risks without raising the chances of heart problems in HBR patients undergoing PCI.
- Objective: To compare the effectiveness of 1 month of APT versus 3 months or more in HBR patients with and without diabetes.
- Methods: The study analyzed data from 4,579 HBR patients, including 1,538 with diabetes, who were randomly assigned to receive either abbreviated or standard APT.
- Results:
- Patients with diabetes had a higher risk of major heart or brain events.
- Both abbreviated and standard APT showed similar rates of adverse events and bleeding.
- Abbreviated APT resulted in less major or clinically relevant bleeding.
Conclusions
The study concluded that patients with or without diabetes experienced similar rates of heart-related events and lower bleeding rates with abbreviated APT. Therefore, diabetes status does not affect the benefits of abbreviated therapy in HBR patients after receiving a specific type of stent.
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