Public Health Study Overview The IPAT trial is a study aimed at preventing Alzheimer’s disease by examining how lowering high systolic blood pressure (SBP) affects brain health in older adults. This study will last for 2 years and is currently recruiting participants. Key Details Study Duration: October 2022 – September 2025 Participants Needed: 180 individuals…
Public Health Update on Cognitive Decline Interventions Background Multidomain lifestyle changes may help slow down cognitive decline and prevent dementia. The U.S. POINTER trial is a significant study looking at how these lifestyle changes affect older adults at risk of cognitive issues. Methods We created four scores to measure how well participants engaged in the…
Drug Development Overview Background Abnormal glucose metabolism in Alzheimer’s Disease (AD) is linked to cognitive issues. This is similar to what happens with a lack of thiamine (vitamin B1) in the brain. In animal studies, thiamine deficiency leads to memory loss, neuron damage, brain inflammation, and other AD-like symptoms. Increasing thiamine levels significantly using benfotiamine…
Drug Development Overview Background Patients with Alzheimer’s disease (AD) often face challenging neuropsychiatric symptoms, like agitation. This can lead to increased stress for caregivers and more placements in long-term care facilities. AXS-05, a new drug combining dextromethorphan and bupropion, is being studied for treating AD agitation (ADA). It is already FDA-approved for major depressive disorder.…
Drug Development LatAm-FINGERS Trial Overview The LatAm-FINGERS trial is a groundbreaking clinical study involving participants from 12 Latin American countries. This trial focuses on providing inclusive and diverse recruitment, especially for underserved populations. Methodology This trial is a multicenter randomized study that assesses a lifestyle intervention designed for the Latin American community. Key features include:…
Drug Development in Alzheimer’s Disease Trials Background In Alzheimer’s Disease (AD) trials, we use clinical scales to measure how well treatments work. To improve the accuracy of trial results, we can use machine learning to create AI-generated digital twins. These digital twins give us personalized predictions of how a patient’s condition might change if they…
Drug Development Study Overview This clinical trial examined the use of transcutaneous vagus nerve stimulation (tVNS) to help improve memory and cognitive function in participants with mild cognitive impairment (MCI). Trial Details The study had a randomized, double-blind, placebo-controlled crossover design. A total of 59 participants with MCI were divided into two groups: one received…
Drug Development Study Overview The study titled “Acute Exercise Response on Brain Imaging and Cognition (AEROBIC)” investigates how aerobic exercise affects brain health in older adults. It includes both cognitively healthy and impaired individuals aged 60 and above. Key Findings Exercise Benefits: Aerobic exercise significantly improves brain metabolism, as shown by changes in glucose levels…
Dementia Care Research and Psychosocial Factors Study Overview This study, published in Alzheimers Dement, focuses on improving dementia awareness and reducing stigma among healthcare workers and the public. Background Many people lack knowledge about dementia, leading to stigma and discrimination. To combat this, we need effective interventions that are based on evidence. Methodology We conducted…
Technology and Dementia Preconference Background Alzheimer’s disease (AD) is a major global health issue that requires new treatment methods. Recent advancements in medical devices using biophoton technology have shown promise in enhancing the cognitive abilities and quality of life for AD patients. Method This study was a randomized, triple-blinded, placebo-controlled clinical trial aimed at determining…
The Newborn Behaviour Observation (NBO) System: A Study in Iceland Study Overview The Newborn Behaviour Observation system (NBO) is a helpful tool for parents to understand their newborns better. This study aimed to see how this system affects mothers’ confidence in the first month after giving birth and the quality of interactions between mothers and…
The Impact of Hand and Foot Exercises on Women with Breast Cancer Study Overview This study investigates how hand and foot exercises influence peripheral neuropathy and overall quality of life in women undergoing chemotherapy for breast cancer. Importance of the Study Peripheral neuropathy can greatly affect patients’ lives. This research aims to identify supportive care…
Study on At-Home Teeth Bleaching with 10% Carbamide Peroxide Background This study tested if using 10% carbamide peroxide (CP) for 2 or 4 hours daily is as effective as using it for 8 hours daily. Methods A total of 120 healthy adults with teeth shades A2 or darker participated. They were divided into three groups…
Testing the Heart Failure Activity Coach Study (HEALTHY) Background Heart failure (HF) is a serious condition linked to a lack of physical activity. While many patients survive their first year after diagnosis, being inactive can lead to higher mortality rates and lower quality of life. Objective This study aimed to evaluate how well we could…
Understanding Patient Experiences with Eosinophilic Esophagitis (EoE) Purpose of the Study Eosinophilic esophagitis (EoE) is a long-term immune-related disease that causes symptoms like: Difficulty swallowing (dysphagia) Food getting stuck Abdominal pain Vomiting Heartburn This condition can significantly lower quality of life due to its physical and emotional effects. This study aimed to gather insights from…
Acute Hypoalgesic and Neurophysiological Responses to Lower-Limb Ischaemic Preconditioning Study Overview This study aimed to find out if ischaemic preconditioning (IPC) can help reduce pain and improve muscle response during voluntary movements. Healthy participants took part in three sessions after getting familiar with the procedures. Key Findings Pain Threshold Improvement: After IPC, the pressure pain…
Study Overview This study focuses on improving follow-up care for women treated for cervical precancerous lesions in Ethiopia. Follow-up care is essential to prevent cervical cancer, but many women do not return for necessary check-ups. Our goal is to find effective strategies to encourage these women to adhere to follow-up recommendations. Key Interventions We will…
Efficacy of Tele-EEG in Critically Ill Patients Study Overview This study looked at the effectiveness of Tele-continuous EEG (Tele-cEEG) compared to Tele-routine EEG (Tele-rEEG) for critically ill patients. The main focus was on seizure detection, mortality rates, and functional outcomes. Study Details The research took place over three years in eight hospitals in Thailand. It…
Barriers to Engaging in HIV Care: Insights from the Daraja Clinical Trial Background Many people with HIV face high risks after leaving the hospital. Their survival rates improve significantly when they start attending HIV clinics early and stick to their treatment plans. The Daraja intervention, a tailored management strategy tested in Tanzania, showed positive results…
Short-term WB-EMS in Cancer Patients: Positive Effects After 2 Weeks of Exercise Study Overview This study examined the use of short-term Whole-body electromyostimulation (WB-EMS) for cancer patients who often struggle with intense exercise due to treatment side effects. The goal was to see if WB-EMS training could be effective and practical. Methodology Thirteen cancer patients…