The iTAPP Study: Evaluating the 15-Method in Primary Care Practical Solutions and Value Background: The 15-method is a proven approach for alcohol problems in primary care, as effective as specialized treatment for mild to moderate alcohol dependence in Sweden. A feasibility study in Danish primary care found the method acceptable and feasible. Aims: Evaluate the…
Emotional Awareness and Expression Therapy vs Cognitive Behavioral Therapy for Chronic Pain in Older Veterans: A Randomized Clinical Trial Overview Chronic pain is common and disabling in older adults, and psychological interventions are indicated. However, the gold standard approach, cognitive-behavioral therapy (CBT), produces only modest benefits, and more powerful options are needed. Study Details The…
Theoretical Explanation of the Benefits of a Nutrition Counseling and Meal Delivery Program for Lung Cancer Patients Study Overview A study was conducted to understand how a medically tailored meal delivery program and intensive nutrition counseling helped individuals with lung cancer. The study involved interviews with participants from four cancer centers in the USA. Findings…
Impact of Telemedical Management on Heart Failure Patients with Diabetes Key Findings from the TIM-HF2 Trial The TIM-HF2 study showed that remote patient management (RPM) reduced hospital admissions and mortality in heart failure (HF) patients. This post-hoc analysis focused on HF patients with diabetes, who are at higher risk. Practical Solutions and Value: RPM decreased…
Efficacy and Safety of Transcutaneous Electrical Acupoint Stimulation for Primary Dysmenorrhoea Overview Primary dysmenorrhoea (PD) causes significant physical and psychosocial impacts. This study aims to assess the effectiveness and safety of transcutaneous electrical acupoint stimulation (TEAS) in managing PD symptoms. Study Design 60 participants with moderate to severe PD will be recruited and randomly assigned…
Molecular Detection of SARS-CoV-2 From Throat Swabs: Practical Solutions and Value Background Testing for SARS-CoV-2 is crucial for early COVID-19 treatment and controlling the spread of infection. Proper upper respiratory specimen collection is vital for accurate diagnosis. Throat swabs are commonly used for mass testing, but their sensitivity for SARS-CoV-2 diagnosis varies. Objective This study…
Limosilactobacillus reuteri 6475 and Prevention of Early Postmenopausal Bone Loss: A Randomized Clinical Trial Summary Daily supplementation with the probiotic Limosilactobacillus reuteri ATCC PTA 6475 (L reuteri) was tested against a placebo to reduce early postmenopausal bone loss in women aged 50 to 60 years over a 2-year period. The study aimed to evaluate the…
Pain Monitoring in Intensive Care: The Impact of Nociception Level Index on Treatment and Prognosis Background Effective pain management is crucial in critical care, especially after surgery. Clinicians need objective and efficient methods to assess pain in a patient-centered manner. The nociception level (NOL) index offers promise in achieving this through its multi-parameter evaluation. Methods…
Safety and Efficacy of Multi-Target TKI Combined with Nivolumab in Check-Point Inhibitor-Refractory Patients with Advanced NSCLC Study Overview A study published in BMC Cancer explored the use of anlotinib, a multi-target tyrosine kinase inhibitor, in combination with nivolumab in patients with non-small cell lung cancer (NSCLC) who were resistant to immune checkpoint inhibitors (ICIs). Study…
Study Title Utility, acceptability and applicability of a nucleic acid amplification test in comparison with a syndromic approach in the management of sexually transmitted diseases at Mulago National Referral Hospital in Uganda (ASTRHA): protocol for an open-label, randomised controlled trial Abstract Sexually transmitted diseases (STDs) are common in low-income and middle-income countries (LMICs) and are…
Antiplatelet Therapy After Coronary Artery Bypass Surgery: Five-Year Follow-Up Objective To evaluate the impact of different antiplatelet strategies on patient outcomes following coronary artery bypass grafting. Design Five-year follow-up of the randomized DACAB trial (Different Antiplatelet Therapy Strategy After Coronary Artery Bypass Grafting). Participants 500 patients aged 18-80 years who underwent elective coronary artery bypass…
Hypersensitivity to CGRP as a Predictive Biomarker for Migraine Prevention with Erenumab ABSTRACT Background: This study aimed to assess the predictive value of CGRP-induced migraine attacks for the effectiveness of erenumab treatment in individuals with migraine. Methods: 139 participants with migraine underwent a 20-minute infusion with CGRP, followed by a 24-week treatment period with erenumab.…
Longitudinal Neurofunctional Changes in Medication Overuse Headache Patients After Mindfulness Practice Key Findings Mindfulness practice, when added to standard medication, led to significant reduction in headache frequency and improvement in clinical variables in Chronic Migraine associated with Medication Overuse Headache (CM-MOH) patients. The study revealed that patients practicing mindfulness showed increased functional connectivity in brain…
Efficacy of Green Tea Extract Cream on Improvement of Striae Distensae Introduction Striae distensae is a skin condition that often leads to dermatological consultations, causing itch and burning sensation. Green tea extract, containing polyphenols, amino acids, and minerals, has been suggested to improve stretch marks by reducing inflammation, increasing collagen production, fibroblast proliferation, and skin…
Are Dutch Adults Equally Susceptible to Nudging and Pricing Strategies for Healthier Diets? Practical Findings from the Supreme Nudge Supermarket Trial Supermarket interventions aimed at promoting healthier dietary patterns were studied to see if their effectiveness differed based on psychological and grocery shopping characteristics. Findings from the 12-month trial involving Dutch-speaking adults aged 30-80 years…
Expanding Access to Malaria Diagnosis and Treatment Results from a Cluster Randomized Trial in Madagascar Global progress on malaria control has faced challenges in providing universal access to malaria diagnosis and treatment. Community health workers (CHWs) can improve access to malaria care for children under 5 years (CU5), but are often not permitted to treat…
Preventive Effect of Prenatal Maternal Oral Probiotic Supplementation on Neonatal Jaundice (POPS Study): A Protocol for the Randomised Double-Blind Placebo-Controlled Clinical Trial Abstract Neonatal jaundice is a common and life-threatening health problem in newborns due to an excess of bilirubin. Gut flora may influence bilirubin metabolism, and the infant gut microbiome is often similar to…
Comparative Study on Treatment of Facial Vitiligo Published in Arch Dermatol Res. 2024 Jun 8;316(7):350 Loss and absence of melanocytes due to various factors lead to vitiligo, the most common pigmentation disorder. This study aimed to compare the effectiveness and safety of two treatments for facial vitiligo: excimer light with topical tacrolimus ointment 0.1% and…
Study on the Effect of Multiple Subcisions on Rolling Acne Scars Summary Acne scarring can greatly impact quality of life. Current treatments have limitations, but the subcision technique shows promise for treating rolling acne scars. This study evaluated the effects of multiple subcision treatments compared to no treatment. Methods Five patients with rolling acne scars…
Clinical Trial Results: Long-pulsed nd: YAG Laser Treatment for Nail Psoriasis Overview Nail psoriasis is a challenging condition associated with significant impact on quality of life. This study aimed to evaluate the effectiveness of long-pulsed 1064 nm Nd: YAG laser treatment for fingernail psoriasis using clinical and ultrasonographic assessments. Key Findings After three monthly treatment…