The Impact of Curcumin on Inflammation in Lupus Patients
Study Overview
This study focused on how curcumin, a compound from turmeric, affects inflammation in patients with systemic lupus erythematosus (SLE), a chronic autoimmune disease.
Study Design
Seventy SLE patients aged 18-60 participated in this randomized, triple-blinded, placebo-controlled trial. Out of these, 62 completed the study. The curcumin group took 1000 mg of curcumin daily, while the placebo group took inactive capsules for 10 weeks. Key inflammatory markers were measured before and after the treatment.
Key Findings
Curcumin significantly reduced two important inflammatory markers:
- Anti-double stranded DNA (anti-ds DNA): Decreased from 52.57 to 43.27 (p = 0.014)
- Interleukin-6 (IL-6): Decreased from 127.11 to 101.49 (p = 0.002)
Compared to the placebo group, those taking curcumin showed significant improvements in these markers by the end of the study.
Conclusion
Curcumin is a safe and effective treatment that helps reduce inflammation and autoimmune activity in SLE patients by lowering anti-ds DNA and IL-6 levels.
Clinical Trial Registration
Registered at: irct.behdasht.gov.ir, Identifier: IRCT20210425051077N1.
Value of Clinical Trials
Clinical trials are essential for developing safe and effective treatments. It’s important to integrate their findings into everyday medical practice.
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