Significant Improvements in Atopic Dermatitis with Rocatinlimab Study Overview In a recent clinical trial, adult patients with moderate-to-severe atopic dermatitis (AD) were treated with rocatinlimab. This treatment showed **significant clinical improvements** compared to a placebo, particularly in the overall Eczema Area and Severity Index (EASI) score. Focus on Head and Neck Region AD often affects…
The Effectiveness of a Problem-Solving Intervention in the Workplace Study Overview This study examines a problem-solving intervention with workplace involvement (PSI-WPI) aimed at reducing sick leave and improving work ability among employees. It focuses on individuals experiencing mild to moderate mental health issues after a sick leave episode. Key Findings Participants: 199 individuals were invited,…
Comparison of Teneligliptin and Luseogliflozin on Pancreatic β-cell Function Study Overview This study aims to compare the effects of two medications, SGLT2 inhibitors (luseogliflozin) and DPP-4 inhibitors (teneligliptin), on pancreatic β-cell function in patients with type 2 diabetes. Study Details We conducted a 26-week study with 103 patients who had type 2 diabetes. Participants were…
Long-Term Effects of Antenatal Betamethasone: Key Findings Study Overview This study looked at the health and social outcomes of individuals who were exposed to antenatal betamethasone 50 years ago. Antenatal corticosteroids are given to pregnant women at risk of preterm birth to help reduce complications for newborns. Methodology We followed 424 adults whose mothers participated…
Study on Pain Management for Chronic Low Back Pain Objective Chronic low back pain (CLBP) is a common health issue. This study aims to see if combining Pain Neuroscience Education (PNE) with neuromuscular exercises (NMS) can improve pain and overall well-being more than using NMS alone. Methods We will conduct a trial with 60 participants…
National Liver Cancer Screening Trial (TRACER) Study Overview Background HCC Screening Recommendations: Guidelines suggest screening for liver cancer (HCC) in high-risk patients using ultrasound every six months, sometimes combined with a blood test for alpha-fetoprotein (AFP). However, this method often lacks effectiveness due to low patient adherence and sensitivity. Potential Solution: Blood-based biomarker panels, like…
Understanding the Impact of Acupuncture on Generalized Anxiety Disorder Introduction: Generalized Anxiety Disorder (GAD) is a common mental health issue that often starts in adolescence or early adulthood. It results in persistent anxiety and can be worsened by Partial Sleep Deprivation (PSD), which is a significant risk factor for developing GAD. This condition can affect…
Whole-Volume Histogram Analysis of Spectral-Computed Tomography Iodine Maps in Gastric Cancer Background Surgery is the main treatment for gastric cancer (GC), but finding effective alternatives for patients who cannot have surgery is important. About 15%-20% of advanced GC cases show HER2 overexpression, which influences treatment choices. Spectral-computed tomography (sCT) helps measure material compositions, and its…
Biomarkers of Glucose-Insulin Homeostasis and Their Impact on Type 2 Diabetes and Cardiovascular Disease Study Overview This study investigates how certain biomarkers related to glucose and insulin levels can predict the risk of developing type 2 diabetes (T2D) and cardiovascular disease (CVD). It also explores whether vitamin D and omega-3 fatty acids can influence these…
Study Overview This study explored the effects of a 6-week treatment with two types of probiotics on patients with diarrhea-predominant irritable bowel syndrome (IBS-D). Background IBS-D patients often experience increased intestinal permeability. Probiotics may help improve IBS symptoms and support gut health. Aim The study aimed to see how Limosilactobacillus reuteri ATCC PTA 6475 (single…
WITHDRAWN: New Thyroid Biopsy Study Overview The article titled “New thyroid fine needle aspiration biopsy needle” was published on July 15, 2014, but has been withdrawn. This decision was made by the Editors in Chief, Prof Aled Rees and Prof Maralyn Druce, in agreement with John Wiley and Sons Ltd. The withdrawal occurred because the…
Cost-Effectiveness of a Rehabilitation Program for Post-COVID-19 Patients Background After the COVID-19 pandemic, many people suffer from ongoing physical and mental health issues. Currently, there is no specific treatment for the various symptoms of post-COVID-19 condition. Rehabilitation programs may help improve the quality of life for these patients. This study examines the cost-effectiveness of a…
The Effectiveness of Combined Exercises and Therapy for Scoliosis in Teens Study Overview Adolescent idiopathic scoliosis (AIS) causes spinal curvature and trunk deformities in teens. This study looked at how well combined physiotherapeutic scoliosis-specific exercises (PSSE) and manual therapy (MT) work in treating AIS symptoms. Research Methodology Thirty-one teens with AIS, having a Cobb angle…
Serum Albumin Level and Delirium in Critically Ill Adults Background Low serum albumin levels (hypoalbuminemia) are linked to a higher risk of delirium in hospitalized patients. However, how these levels affect the duration and severity of delirium is not well understood. Objective The goal of this study was to explore the connection between serum albumin…
Effectiveness of King’s Theory of Goal Attainment in Blood Glucose Management Overview Diabetes is a major health issue worldwide, with millions affected. In China, around 140 million people have diabetes, and many struggle to follow their treatment plans. This study focuses on helping newly diagnosed type 2 diabetes patients manage their blood sugar levels effectively…
Diagnosis of New Cancer After Cryptogenic Stroke Study Overview This study aimed to understand how often and when new cancers are diagnosed in patients who had a cryptogenic stroke. Study Methods We analyzed data from the ARCADIA trial, which included patients with cryptogenic stroke and atrial cardiopathy. Participants were monitored closely, and any serious health…
Spinal Cord Stimulation and Exercise for Persistent Spinal Pain Syndrome Study Overview This study investigates how spinal cord stimulation (SCS) combined with exercise can help patients with persistent spinal pain syndrome (PSPS-T2). The goal is to see if this combination can reduce pain, improve quality of life, and decrease disability. Study Design We are conducting…
Safety and Tolerability of Tegoprubart in ALS Patients: A Phase 2A Clinical Trial Study Overview This study focused on the safety and tolerability of tegoprubart, an anti-CD40L antibody, in patients with amyotrophic lateral sclerosis (ALS). The goal was to understand how it affects inflammation in the body. Key Findings Participants: 54 ALS patients received 6…
Effective Treatment for Knee Osteoarthritis with PRP Injections Study Overview: This study investigates the effectiveness of autologous platelet rich plasma (PRP) injections in treating knee osteoarthritis (KOA). It examines how these injections affect important biomarkers: interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP). Methodology: 150 KOA patients from the Third Hospital…
Phase II Study of uPAR-PET/CT in Breast Cancer Staging Overview Accurate staging of breast cancer is vital for effective treatment planning. Currently, no imaging method reliably detects lymph node metastases before surgery. Therefore, about 70% of patients rely on sentinel node procedures for determining their N status. Study Details In a clinical trial involving 49…