Treatment group
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseValidation and modification of existing bleeding complications prediction models for percutaneous renal biopsy: a prospective study
Validation and Modification of Bleeding Risk Models for Kidney Biopsy Study Overview This study focuses on the risk of bleeding complications after a percutaneous renal biopsy (PRB), a common procedure. The goal was to improve existing models that predict these complications, aiding doctors in making better decisions. Methods Used Researchers analyzed data from 471 patients […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe impact of physical exercise with additional visual tasks on UDVA and accommodation sensitivity in children: the mediating role of kinetic visual acuity
The Impact of Exercise and Visual Tasks on Children’s Vision Study Overview: This study looked at how physical exercise combined with visual tasks affects children’s vision. It specifically measured uncorrected distance visual acuity (UDVA), kinetic visual acuity (KVA), and accommodation sensitivity. Methodology: A total of 168 third-grade students participated, divided into two groups: Experimental Group […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseLiposomal Bupivacaine Use in Third Molar Impaction Surgery: INNOVATE Study
Liposomal Bupivacaine Use in Third Molar Impaction Surgery: INNOVATE Study Study Overview This study assessed the effectiveness and safety of liposomal bupivacaine (LB) for pain relief after third molar extraction. It was a phase 3, double-blind, placebo-controlled trial involving patients who underwent bilateral third molar extractions. Study Design Participants were randomly assigned to receive either […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImpact of chronic intranasal oxytocin administration on face expression processing in autistic children: a randomized controlled trial using fMRI
Impact of Oxytocin on Facial Expression Processing in Autistic Children Study Overview This study explored how intranasal oxytocin might help autistic children understand facial expressions better. Autism often leads to challenges in social communication, particularly with reading non-verbal cues like facial expressions. Oxytocin could help by making these social signals more noticeable or by lowering […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAccuracy and user experience of dental diagnosis of a patient with cleidocranial dysplasia using immersive virtual reality and cone-beam computed tomography multiplanar reconstructions
Study Overview This study examined how accurate and user-friendly dental diagnosis is for a patient with cleidocranial dysplasia (CCD) using immersive virtual reality (VR) and cone-beam computed tomography (CBCT). Methods Forty dental students were divided into two groups: one using VR and the other using traditional CBCT methods. The VR group interacted with a 3D […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCombined fractional CO2 laser 10,600 nm with methotrexate 1% gel versus methotrexate 1% gel alone in the treatment of nail psoriasis: a randomized comparative study
Study Overview This study compares the effectiveness of a combined treatment using fractional CO2 laser and methotrexate gel against using methotrexate gel alone for nail psoriasis. Key Findings Effective Treatments: Both treatments improved nail psoriasis significantly after 4 months. Longer Lasting Results: The laser-assisted treatment showed better results 3 months after the treatment ended. Improved […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseOptimization of a Mobile Transdiagnostic Emotion Regulation Intervention for University Students: A Micro-Randomized Trial
Optimizing a Mobile Emotion Regulation Intervention for University Students Overview University students are facing increasing mental health challenges. To address this, we created a mobile intervention called ROOM that helps students develop better emotion regulation (ER) skills. Our goal was to understand how ROOM works and improve its content and delivery. Study Details We conducted […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseFactors associated with male recruitment in a multi-site randomized behavioral clinical trial targeting the metabolic syndrome: analysis of screening and recruitment data from the ELM trial
Factors Affecting Male Participation in a Behavioral Clinical Trial Background Males are often underrepresented in lifestyle-related clinical trials. This study aimed to explore what influences men’s interest in participating in a multi-site trial focused on lifestyle changes for metabolic syndrome. We also compared these findings with female participation to identify any differences. Methods We analyzed […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effects of the active break intervention on nonspecific low back pain among young people: a randomized controlled trial
Effects of Active Break Intervention on Low Back Pain in Young People Study Overview This study focused on how the Active Break program can help reduce low back pain (LBP) in young people. Prolonged sitting, especially in a bent position, can lead to discomfort and is linked to LBP. Our goal was to see if […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEnhancing medical education with chatbots: a randomized controlled trial on standardized patients for colorectal cancer
Enhancing Medical Education with Chatbots A Study on Colorectal Cancer Training Published: BMC Med Educ. December 20, 2024 Introduction Standardized Patients (SP) and Case-Based Learning (CBL) are widely used in medical education. However, traditional SP methods might not effectively help students grasp basic medical knowledge or develop clinical thinking. We need to innovate these methods […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAddressing treatment switching in the ALTA-1L trial with g-methods: exploring the impact of model specification
Addressing Treatment Switching in the ALTA-1L Trial Background Treatment switching in clinical trials can complicate understanding the true effects of treatments. Standard analyses may not show the real impact when patients switch treatments. For instance, the ALTA-1L trial suggested that brigatinib might lead to better overall survival compared to crizotinib if no switching occurred. A […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseInfluence of liberal versus conservative oxygen therapies on the hemodynamic parameters of mechanically ventilated patients with sepsis: a randomized clinical trial
Influence of Oxygen Therapies on Patients with Sepsis Study Overview This study explored how different oxygen therapies affect patients with sepsis who are on mechanical ventilation. We compared two approaches: liberal oxygen therapy (target SpO2 ≥ 96%) and conservative oxygen therapy (target SpO2 88-92%). Key Findings No significant difference in stroke volume and cardiac output […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDesigning Positive Psychology Interventions for Social Media: Cross-Sectional Web-Based Experiment With Young Adults With Cancer
Designing Positive Psychology Interventions for Social Media Study Overview Young adults aged 18-39 with cancer often face serious mental health challenges. This study explores how positive psychology messages on social media can help improve their well-being. Study Goals The main aim was to see if social media messages based on positive psychology could: Encourage young […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseUnderstanding the Effectiveness of Water, Sanitation, and Hygiene Interventions: A Counterfactual Simulation Approach to Generalizing the Outcomes of Intervention Trials
Understanding the Effectiveness of Water, Sanitation, and Hygiene Interventions Background Water, sanitation, and hygiene (WASH) interventions can help reduce diarrheal diseases. However, many large trials have not shown the expected health benefits for young children in low-resource areas. We need better guidance to improve these interventions and overcome challenges in reducing diarrheal diseases. Objectives Our […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Pharmacist-Led Management Model and Medication Adherence Among Patients With Chronic Heart Failure: A Randomized Clinical Trial
Pharmacist-Led Management Model and Medication Adherence Among Patients With Chronic Heart Failure Overview Importance: Poor medication adherence in patients with Chronic Heart Failure (CHF) can lead to serious health issues, especially in China. Objective: To evaluate whether a pharmacist-led management model using a social media platform improves medication adherence compared to regular care. Study Details: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseApplication of Three Types of Scaffolds in Pulp Regeneration for Permanent Mature Teeth with Periapical Lesions: A Randomized Controlled Trial
Application of Three Types of Scaffolds in Pulp Regeneration for Permanent Mature Teeth with Periapical Lesions Objective This study aimed to compare different scaffolds for pulp regeneration in mature teeth with apical lesions. We looked at native chitosan-based scaffolds versus enzymatically modified chitosan-based scaffolds using clinical and radiographic methods. Methods Participants aged 15-45 with necrotic […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseClinical outcomes of selective removal to soft dentin versus firm dentin for deep caries lesions: a randomized controlled trial up to 5 years
Clinical Outcomes of Selective Dentin Removal for Deep Caries Study Overview This study compared two methods for treating deep caries in permanent teeth: selective removal to soft dentin (SRSD) with or without calcium silicate (CS) and selective removal to firm dentin (SRFD). Study Details Conducted from November 2018 to March 2020, the study involved 165 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of a multimodal therapy protocol for the management of allergic rhinitis: a randomized controlled trial
Effectiveness of a Multimodal Therapy for Allergic Rhinitis Study Overview This study investigates how well a multimodal therapy works for treating allergic rhinitis. Study Design We conducted a randomized controlled trial with 100 patients. They were divided into two groups: one received multimodal therapy while the other received standard treatment. Each group had 50 patients […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of transcutaneous electro-stimulation in postoperative rehabilitation pain treatment in thoracic surgery: a randomized clinical trial
Effect of Transcutaneous Electro-Stimulation on Postoperative Pain in Thoracic Surgery Background Chest pain after thoracic surgery is a challenging issue. Proper pain management is essential to prevent complications like ineffective coughing and shallow breathing. Methods This study aimed to evaluate the effectiveness of transcutaneous electrical stimulation (TENS) in managing postoperative pain after thoracotomy. A total […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy of 4% tetracaine gel and lidocaine-prilocaine cream in reducing local anesthetic injection pain in upper eyelid blepharoplasty: a randomized, single-blinded, controlled trial
Efficacy of 4% Tetracaine Gel vs. Lidocaine-Prilocaine Cream for Eyelid Surgery Pain Relief Background Local anesthetic injections can be very painful, which may discourage patients from accepting necessary procedures. Objective This study aimed to compare the effectiveness and side effects of 4% tetracaine gel (TG) and lidocaine-prilocaine cream (LPC) in reducing pain during local anesthetic […] ➡️➡️➡️