Community Versus Facility-Based Services for Hepatitis C Screening in Cambodia Background: Hepatitis C is a major health issue in Cambodia, especially for those over 45 years old, with a prevalence of 5%. Improving access to screening and treatment is essential for eliminating hepatitis C. Objective: This study will compare the effectiveness of community-based screening versus…
Acute Severe Pain in Emergency Department: Morphine vs. Low-Dose Ketamine Introduction Severe pain is a critical issue that can be dangerous due to its location and potential misdiagnosis. Aim This study aimed to compare the effectiveness of morphine and low-dose ketamine for treating severe pain in the emergency department. Methods We conducted a randomized open…
New Solutions for Treating Chronic Recurrent Cystitis in Women: Experience with Superlymph Introduction Chronic recurrent cystitis is a common and challenging issue in urology. Traditional antimicrobial treatments often fail to provide long-term relief. Aim This study aimed to assess the effectiveness and safety of the drug Superlymph, administered through rectal and vaginal suppositories in two…
Experience with UroBest in Patients with Acute Cystitis Study Overview AIM: This study aimed to assess how effective and safe UroBest is for treating acute cystitis compared to similar products. Methods The study involved 90 patients aged 18 to 49 with acute cystitis. They were treated at various clinical sites in Russia. All patients received…
Study of the Pharmacokinetics of Extended Release Sildenafil Purpose of the Study The study aimed to compare how the drug Vildegra, approved in Russia, behaves in the body compared to the original drug, Viagra. Materials and Methods The study was designed as a prospective, open-label trial involving healthy male volunteers. A total of 48 men,…
Quality of Life in Patients with Subcutaneous or Transvenous Implantable Cardioverter-Defibrillators Study Overview The subcutaneous implantable cardioverter-defibrillator (S-ICD) was designed to reduce complications linked to the transvenous version (TV-ICD). This study looks at how these two devices affect patients’ quality of life. Methodology In the PRAETORIAN trial, patients needing an implantable cardioverter-defibrillator were randomly assigned…
Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for Demodex Blepharitis Purpose This study aimed to test how well a treatment using terpinen-4-ol (T4O) and eyelid deep cleaning works for Demodex blepharitis. Methods We conducted a trial with 40 patients diagnosed with Demodex blepharitis at the Cornea Specialty Clinic of Hankou Aier Eye Hospital. Participants…
Clinical Trial on Focused Extracorporeal Shock-Wave Therapy for Cervical Spondylosis Study Overview Extracorporeal Shock Wave Therapy (ESWT) is a modern physiotherapy treatment that helps with muscle and bone issues. This study specifically looked at how effective focused ESWT (fESWT) is for relieving pain and improving function in patients with cervical spondylosis, a neck condition. Study…
Understanding the Impact of AI Explanations on Radiology Study Overview This study explores how different types of AI explanations affect the ability of doctors to diagnose chest X-rays and their trust in AI. It aimed to find out if AI explanations help or hinder doctors in making decisions. Research Details The study was conducted from…
Survival Outcomes of Colonoscopy Screening: Key Findings Background Colonoscopy is a common method used to screen for colorectal cancer, but strong evidence supporting its effectiveness is lacking. The NordICC trial, the first randomized study on colonoscopy screening, showed no clear benefits for the general population. However, some benefits were suggested for specific groups. This study…
Study Overview This study examined how effective low-load resistance training with blood flow restriction (LRT-BFR) is compared to conventional high-intensity resistance training (CRT) for older adults with sarcopenia. Key Findings Participants: 21 older adults (65 years and older) diagnosed with sarcopenia. Training Groups: LRT-BFR: 20%-30% of one-repetition maximum (1RM) CRT: 60%-70% of 1RM Duration: 12…
Study Overview This study compares the effectiveness of standard-dose and low-dose cone-beam computed tomography (CBCT) in diagnosing and treating impacted mandibular third molars (M3Ms). Objective The goal was to see how well low-dose CBCT shows the mandibular canal (MC) and its closeness to M3Ms, and how this affects decisions made by dental professionals. Methods A…
A Synbiotic Mixture for Managing Infantile Colic Study Overview This study investigates the effectiveness of a synbiotic (Bactecal D Liquid) for infants experiencing colic, which is characterized by excessive crying and irritability. A total of 68 infants were involved in a randomized trial, where they received either one or two doses of the synbiotic daily…
Clinical Study on Moxibustion and Cisplatin for Malignant Pleural Effusion Objective The study aimed to assess the effectiveness of combining heat-sensitive moxibustion with intrapleural cisplatin infusion compared to cisplatin infusion alone in treating malignant pleural effusion (MPE). Methods Forty patients with MPE were randomly divided into two groups: an observation group (20 patients) and a…
Hand-Arm Bimanual Intensive Therapy for Infants with Unilateral Cerebral Palsy Study Overview This clinical trial aimed to find out if the Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) can help improve motor skills in infants with unilateral cerebral palsy (UCP). Why It Matters Identifying cerebral palsy early and using effective therapies can significantly enhance…
Correlation of CTCAE and Patient-Reported Breast Radiation Dermatitis Symptoms Study Overview This study looks at how the CTCAE scale, used by doctors to grade radiation dermatitis (RD), relates to symptoms reported by patients. It examines the connection between CTCAE scores and patient experiences using two assessment tools: the Skin Symptom Assessment (SSA) and the Radiation-Induced…
Embodied Cognition Driven Qigong: Managing Depression and Preventing Relapse in Substance Use Disorders Objective Substance use disorders (SUDs) are a major public health issue, with high relapse rates. This study aimed to explore factors that influence relapse and to test a Health Qigong intervention to help manage these issues. Methods We surveyed 398 male substance…
Immunogenicity of Adalimumab Reference Product vs. Adalimumab-adbm Study Overview This analysis looked at the immunogenicity of a biosimilar drug, adalimumab-adbm (Cyltezo), compared to the original adalimumab (Humira) in patients with rheumatoid arthritis, Crohn’s disease, and chronic plaque psoriasis. Study Details In the VOLTAIRE trials, researchers measured the presence of antidrug antibodies (ADAs) and neutralizing antibodies…
Accuracy of Healthcare Data in Identifying Cardiovascular Outcomes After Stroke Background Healthcare systems data (HCSD) can make clinical trials more efficient, but their accuracy is not always clear. This study aimed to evaluate how accurate HCSD is for detecting outcomes in the RESTART trial, comparing it to follow-up questionnaires. Methods RESTART was a clinical trial…
Effectiveness of Flaxseed and Fasting Mimicking Diet in Managing MASLD Study Overview This study explored how combining flaxseed and a fasting mimicking diet (FMD) affects patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). While both treatments have shown benefits individually, their combined effect was unclear. Study Design Conducted over 12 weeks, this randomized trial involved…