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68Ga-DOTA-D-Alanine-BoroPro Radiotracer for Imaging of the Fibroblast Activation Protein in Malignant and Non-Malignant Diseases
Summary
- A new radiotracer, 68Ga-iFAP, has been developed for PET imaging to detect fibroblast activation protein (FAP) in tumors and non-malignant tissues.
- The radiotracer showed high specificity for FAP and provided clear visualization of glioblastoma, breast tumor, prostate cancer, and myocardial infarction sites in preclinical and human studies.
- The research supports the need for further clinical trials to confirm the effectiveness of 68Ga-iFAP PET imaging for FAP expression.
Practical Solutions and Value
- 68Ga-iFAP offers a practical solution for non-invasive imaging of FAP expression in both malignant and non-malignant conditions, aiding in diagnosis and treatment monitoring.
- The radiotracer’s rapid renal elimination and high specificity for FAP make it a valuable tool for precise visualization of FAP expression in various diseases.
- These findings support the potential of 68Ga-iFAP PET imaging to improve patient care by providing accurate information about FAP expression in different medical conditions.
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