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Comparison of novel PSMA-targeting [177Lu]Lu-P17-087 with its albumin binding derivative [177Lu]Lu-P17-088 in metastatic castration-resistant prostate cancer patients: a first-in-human study

Dr M. Trenton

Dr M. Trenton

Comparison of novel PSMA-targeting [177Lu]Lu-P17-087 with its albumin binding derivative [177Lu]Lu-P17-088 in metastatic castration-resistant prostate cancer patients: a first-in-human study

Comparison of novel PSMA-targeting [<sup>177</sup>Lu]Lu-P17-087 with its albumin binding derivative [<sup>177</sup>Lu]Lu-P17-088 in metastatic castration-resistant prostate cancer patients: a first-in-human study” width=”500″ height=”auto” /></figure> <p>“`html</p> <h3>Study on PSMA-Targeting Radionuclide Therapy for Prostate Cancer</h3> <h4>Purpose:</h4> <ul> <li>Assess PSMA-targeting radionuclide therapy for prostate cancer</li> <li>Evaluate dosimetry and radiation toxicity</li> <li>Explore PSA response in metastatic castration-resistant prostate cancer (mCRPC) patients</li> </ul> <h4>Methods:</h4> <ul> <li>Patients with PSMA-positive tumors enrolled after PET/CT scan</li> <li>Five patients received [177Lu]Lu-P17-087 and four received [177Lu]Lu-P17-088</li> <li>Imaging and dosimetry evaluations were performed for both patient groups</li> </ul> <h4>Results:</h4> <ul> <li>No major clinical side-effects observed with low dose treatment</li> <li>[177Lu]Lu-P17-088 exhibited higher effective doses than [177Lu]Lu-P17-087</li> <li>[177Lu]Lu-P17-087 demonstrated excellent tumor uptake and faster kinetics</li> <li>[177Lu]Lu-P17-088 showed slower washout and higher average dose</li> <li>Reduction in PSA values observed in patients receiving both agents</li> </ul> <h4>Conclusion:</h4> <ul> <li>[177Lu]Lu-P17-088 and [177Lu]Lu-P17-087 are promising for personalized treatment of mCRPC</li> <li>Further studies are needed to evaluate potential therapeutic efficacy</li> </ul> <p>Find the trial registration <a href=here.

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