Trends in antenatal corticosteroid administration: did our timing improve?

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Analysis of Antenatal Corticosteroid Prophylaxis Effectiveness

Objective:

• Examine trends in effective antenatal corticosteroid prophylaxis (ACS) use for preterm birth-related diagnoses.

Methods:

• Retrospective study using delivery data at Charité Berlin, Germany from 2014 to 2020.
• Evaluate the rate of effective ACS administrations (≤10 days before delivery) and the percentage of post-ACS deliveries at or after 37 weeks.
• Investigate conditions associated with ineffective ACS administrations.

Results:

• Overall effective ACS rate: 42% (709 out of 1,672).
• Post-ACS deliveries at or after 37 weeks: 19% (343).
• Placenta previa, twin pregnancy, and isthmocervical insufficiency linked to ineffective ACS (19-34% effective).
• Increasing trend of ACS effectiveness over the study period (p=0.002).
• Improvement in ACS effectiveness for placental dysfunction and isthmocervical insufficiency diagnoses (p=0.028; p=0.001).

Conclusions:

• Decrease in post-ACS deliveries at or after 37 weeks compared to previous findings (19% vs. 27%).
• Frequent ineffective ACS administrations in patients with specific conditions.
• Potential for new diagnostic tools to enhance ACS effectiveness.

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Full Clinical Trial Report Trends in antenatal corticosteroid administration: did our timing improve?: https://pubmed.ncbi.nlm.nih.gov/38662540/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1B1L42DK3a-JWCV4P_PtHHBmWjwBLFNcDXsYJkbqjQD0Ca7UQh&fc=None&ff=20240425230036&v=2.18.0.post9+e462414