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Immunohistochemistry of Lung Cancer Biomarkers
Practical Solutions and Value
- Immunohistochemical (IHC) staining is a cost-effective testing method for pulmonary biomarker testing.
- Specific antibody clones for certain genetic alterations, such as anaplastic lymphoma kinase, ROS-1, and neurotrophic tropmyosin receptor kinase, have provided robust results for targeted therapy.
- IHC can be used as a primary testing or screening method to direct targeted therapy.
- It is also utilized as a predictive marker for response to immunotherapy through evaluation of programmed death ligand 1 expression.
- Antibody-drug conjugates (ADCs) under investigation are designed to deliver drugs directly to tumor cells through binding to specific target antigens.
- ADCs have received accelerated FDA approval, and IHC is incorporated in many clinical trials evaluating ADC efficacy.
- ADCs may have a companion diagnostic IHC to guide patient selection.
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