Molecular Landscape and Therapeutic Strategies against Colorectal Cancer
Practical Solutions and Value
- Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide.
- Incidence of young-onset CRC (diagnosis before age 50) is increasing.
- Improved outcomes for CRC patients due to comprehensive molecular characterization of tumors and novel therapeutic strategies.
- Advances in genomic and transcriptomic analyses have identified distinct tumor subtypes with unique biological characteristics and therapeutic vulnerabilities.
- Targeted therapies and immunotherapy are now incorporated into CRC treatment.
- Discussion of the molecular landscape and key oncogenes/tumor suppressors contributing to CRC tumorigenesis, metastasis, and therapeutic resistance.
- Personalized therapeutic strategies for subsets of CRC patients.
- Overview of evolving novel treatments being evaluated in clinical trials.
