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Association between Homocysteine and Vitamin D Levels in Asymptomatic Korean Adults
Summary
- An increased homocysteine level is a risk factor for cardiovascular disease, venous thromboembolism, cerebrovascular disease, and chronic kidney disease.
- Vitamin D deficiency is associated with coronary artery disease and metabolic disorders.
- The study included data from 1375 adults (895 men and 480 women) with a mean age of 52.62 Ā± 9.94 years.
- Homocysteine levels were positively associated with age, hypertension, diabetes, smoking habits, and levels of low-density lipoprotein cholesterol, creatinine, uric acid, and high-sensitivity C-reactive protein.
- Vitamin D levels were negatively associated with serum levels of homocysteine after adjusting for covariates.
- Long-term prospective studies are needed to establish a causal relationship between vitamin D status and serum levels of homocysteine in asymptomatic Korean adults.
- An intervention trial is warranted to determine whether vitamin D administration is helpful for the primary prevention of cardiovascular disease by lowering the homocysteine level in this population.
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