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Study Summary: Determining Optimal Bupivacaine Dose for Cesarean Section at High Altitude
At moderately high altitudes, the need for local anesthesia during cesarean sections can be different due to altitude-related changes. This study aimed to find the right dose of bupivacaine for spinal anesthesia during cesarean sections at moderately high altitudes.
Methods and Findings
Thirty parturients at moderate altitude underwent cesarean section under spinal-epidural anesthesia. The study used a sequential method to determine the effective dose of bupivacaine. The median effective dose (ED50) of hyperbaric bupivacaine for spinal anesthesia during cesarean section was found to be 8.23 mg, exceeding the typical ED50 dose at low altitudes. Only 6 parturients experienced hypotension during the operation, and no adverse reactions such as nausea, vomiting, or shivering were observed.
Conclusion and Implications
The study concluded that the optimal dose of hyperbaric bupivacaine for spinal anesthesia during cesarean section at moderately high altitude is 8.23 mg. Further research is needed to determine the ED90 or ED95 dose of local anesthetics for cesarean section at moderately high altitudes to provide better guidance for clinical practice.
PMID: 38681209 | PMC: PMC11048353 | DOI: 10.2147/DDDT.S455844
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