Non-vascular ATP-sensitive potassium channel activation and migraine attacks
Objective
To study the impact of NN414, a specific KATP channel opener, on inducing migraine attacks in individuals with migraine without aura.
Methods
Thirteen participants received NN414 and placebo on separate days. The study measured the difference in migraine attack incidence and other related factors.
Results
Out of twelve participants, two reported migraine attacks after NN414 compared to one after placebo. No significant differences were found in headache intensity, blood flow, artery diameter, heart rate, and blood pressure between NN414 and placebo.
Conclusion
Activation of the Kir6.2/SUR1 channel subtype did not induce migraines, suggesting it may not contribute to migraine development. This study points to KATP channel blockers targeting the Kir6.1/SUR2B subtype as potential candidates for new antimigraine treatments.
Registration number: NCT04744129
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