OpTAT Trial: Improving Adherence to Oral Anticancer Therapies
Summary
A pharmacist-led program improved patient adherence to oral anticancer therapies, specifically implementation, among patients with solid cancers. The program included monthly electronic and motivational feedback, educational support, and behavioral components over 12 months.
Key Findings
Patients in the intervention arm showed consistently higher day-by-day medication implementation compared to the control arm. The intervention did not significantly impact persistence, adherence, beliefs about medicines, or quality of life scores. However, it benefited certain patient groups, including men, those younger than 60 years, and those without metastasis.
Implications
Longer-term medication adherence interventions in clinical practice may contribute to the improvement of progression-free survival for patients with solid cancers.
Trial Registration
ClinicalTrials.gov NCT04484064
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