Developing a Fit-for-Purpose Composite Symptom Score for Malignant Pleural Mesothelioma Clinical Trials
Key Practical Solutions and Value
We developed a composite symptom score (CSS) to measure disease-related symptom burden in patients with malignant pleural mesothelioma (MPM). The CSS, derived from the MD Anderson Symptom Inventory for MPM, includes 5 symptoms: pain, fatigue, shortness of breath, muscle weakness, and coughing. It correlates strongly with the full symptom set and has good sensitivity to worsening disease and quality of life ratings.
The MDASI-MPM CSS can be used in clinical trials to assess treatment outcomes and can be administered frequently, even electronically, to capture symptom trajectories during and after the trial. It addresses multiplicity issues that can arise when multiple symptoms increase due to worsening disease. This approach can be adapted for other advanced-cancer trials.
Practical Applications in Healthcare
Clinical trials are crucial for developing safe and effective treatments, and our AI-driven platform, DocSym, consolidates standards, protocols, and research for easy access by clinicians. Additionally, our mobile apps support scheduling, treatment monitoring, and telemedicine, streamlining operations and expanding digital services in healthcare.
By leveraging AI, clinics can improve workflows, enhance patient outcomes, and reduce paper-based routines. Learn more about our solutions at aidevmd.com.
