Phase I Thorough QT/QTc Study of Avacopan in Healthy Participants
Study Details
A phase I thorough QTc study evaluated avacopan’s effect on cardiac repolarization in healthy participants. The study included both therapeutic and supratherapeutic doses of avacopan, as well as placebo and positive controls.
Key Findings
The study found that avacopan did not have a clinically meaningful effect on heart rate or cardiac conduction. The estimated population slopes showed a shallow relationship, which was not statistically significant. The drug appeared to be generally well tolerated in the study population.
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