Multiplex real-time PCR in non-invasive respiratory samples to reduce antibiotic use in community-acquired pneumonia: a randomised trial
Abstract
We evaluated whether using multiplex real-time PCR in addition to standard microbiological testing is safer and more effective than standard testing alone in reducing antibiotic use for community-acquired pneumonia (CAP). In this randomised trial, adults hospitalized with CAP were enrolled at four Spanish hospitals and randomly assigned to undergo either multiplex real-time PCR plus standard microbiological testing or standard testing alone. The main goal was to measure the days of antibiotic therapy (DOT). The study found that there was no significant difference in antibiotic use between the two groups. However, no differences were observed in adverse events and 30-day mortality. Our findings do not support the routine implementation of multiplex real-time PCR in the initial microbiological testing in hospitalized patients with CAP.
Clinicaltrials.gov registration: NCT04158492
Clinical Trials and AI-Driven Solutions
Clinical trials are fundamental in developing safe and effective treatments. It’s crucial to translate their benefits into everyday medical practice. DocSym, our AI-driven platform, consolidates ICD-11 standards, clinical protocols, and research into a single, easily accessible knowledge base for clinicians.
In today’s healthcare environment, operational efficiency is vital. Our mobile apps support scheduling, monitoring treatments, and telemedicine, making it easier to manage patient care and expand services digitally.
By leveraging AI, clinics can optimize their workflows and enhance patient outcomes, reducing paperwork. Discover more about how we can assist at aidevmd.com.
