The Effect of Tranexamic Acid on Postpartum Bleeding in Women with Anaemia
Study Overview
This study, known as WOMAN-2, looked at whether tranexamic acid can help prevent postpartum bleeding in women with moderate or severe anaemia after childbirth.
Key Details
- Type of Study: International, randomised, double-blind, placebo-controlled trial.
- Location: Conducted in 34 hospitals across Nigeria, Pakistan, Tanzania, and Zambia.
- Participants: Women of any age in active labour with haemoglobin levels below 100 g/L.
- Method: Women were randomly assigned to receive either 1 g of tranexamic acid or a placebo within 15 minutes after childbirth.
Findings
- Out of 16,586 women invited, 7,580 received tranexamic acid and 7,488 received a placebo.
- Postpartum haemorrhage occurred in 7.0% of the tranexamic acid group and 6.6% of the placebo group.
- No serious side effects or treatment-related deaths were reported.
Conclusion
Tranexamic acid did not significantly reduce the risk of postpartum bleeding in women with moderate or severe anaemia when given shortly after childbirth.
Practical Solutions and Value
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