Efficacy and safety of rebamipide/nizatidine in patients with erosive gastritis: A randomized, multicenter, phase 4 study

Efficacy and Safety of Rebamipide/Nizatidine in Erosive Gastritis

Study Overview

This study examines the effectiveness of a combination therapy using rebamipide and nizatidine compared to nizatidine alone in treating erosive gastritis.

Study Details

  • Participants: 260 patients with erosive gastritis.
  • Groups: One group received rebamipide/nizatidine, and the other received nizatidine only.
  • Duration: Treatment lasted for 2 weeks.

Results

  • Primary Outcome: The combination therapy showed a significant improvement in mucosal erosions (62.0% vs. 49.2% for nizatidine alone).
  • Secondary Outcomes: Both groups effectively cured erosions and improved symptoms like bleeding and erythema.
  • Safety: No adverse effects were reported from the treatments.

Conclusion

The combination of rebamipide and nizatidine is effective for treating erosive gastritis.

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