Use of a Personalized Clinical Decision Support System for Dosing in Psychopharmacotherapy in Patients with Alcoholic Hallucinosis Based on Pharmacogenomic Markers

Use of a Personalized Clinical Decision Support System for Dosing in Psychopharmacotherapy in Patients with Alcoholic Hallucinosis Based on Pharmacogenomic Markers

Introduction

Alcoholic hallucinosis (AH) is a serious issue related to chronic alcoholism, causing symptoms like auditory hallucinations and delusions. Haloperidol is a common treatment, but it often has side effects. By using pharmacogenetic testing, specifically focusing on the CYP2D6 gene, we can customize haloperidol dosages, which leads to safer and more effective treatment.

Study Overview

We studied 100 men diagnosed with «psychotic disorder induced by alcohol use» and divided them into two groups:

• Main Group: 45 patients received haloperidol based on pharmacogenetic testing.
• Control Group: 55 patients received the standard dosage.

The study tested the CYP2D6 1846G > A variation and evaluated effectiveness using PANSS, UKU, and SAS scales.

Results

The CYP2D6 gene variations were similar in both groups. However, the main group showed:

• Fewer side effects.
• Better improvement in psychotic symptoms.

Differences were statistically significant on days 3-5 of treatment according to UKU, SAS, and PANSS scales.

Conclusion

Adjusting haloperidol dosage through pharmacogenetic testing significantly enhances treatment tolerance and speeds up the recovery of psychotic symptoms in patients with alcoholic hallucinosis. This highlights the importance of a personalized approach in psychopharmacotherapy.

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