Hydroxychloroquine Improves Health in Obese Women with PCOS
Study Overview
Hydroxychloroquine (HCQ) is commonly used for immune disorders and shows promise in helping obese women with polycystic ovary syndrome (PCOS) by lowering blood sugar levels. However, how it works is still not fully understood.
Study Purpose
This study aimed to see how HCQ affects blood sugar, fat levels, and hormone levels in obese women with PCOS.
Methodology
Fifty obese women with PCOS participated in the study. They were divided into two groups:
- HCQ Group: 25 women received 200 mg of hydroxychloroquine daily.
- Metformin Group: 25 women received 1000 mg of metformin daily.
The researchers measured body fat, blood sugar, fat levels, and hormones. They also tracked pregnancies for six months after treatment.
Key Findings
After treatment:
- Both groups improved in body fat and blood sugar control.
- The HCQ group had a better increase in insulin sensitivity compared to the Metformin group.
- Fat levels (cholesterol and triglycerides) decreased more in the HCQ group.
- Hormone levels did not show significant changes, but there was a slight overall improvement.
Conclusion
HCQ may be beneficial for managing obesity in women with PCOS by improving body fat distribution and blood sugar and fat levels.
Clinical Trial Registration
This study was registered on April 17, 2022, with the registration number ChiCTR2200058816. You can find more details here.
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