Right Ventricular Strain Impairment Due to Hypoxia in COPD Patients
Study Overview
This study looks at how low oxygen levels affect the right side of the heart in patients with Chronic Obstructive Pulmonary Disease (COPD). We analyzed data from two clinical trials to understand the impact of high altitude on heart function.
Key Findings
- Background: Low oxygen can raise blood pressure in the lungs, leading to heart problems.
- Methods: We studied 54 COPD patients who traveled from 760 meters to 3100 meters over two days. We measured their heart function using a sensitive technique called RV free wall strain (RVFWS).
- Results:
- RVFWS decreased from -26.0% to -23.9%, indicating worsening heart function.
- The percentage of patients showing significant heart dysfunction increased from 7.4% to 25.9% at higher altitude.
Conclusion
More than 25% of COPD patients showed signs of heart dysfunction due to low oxygen levels. Using RVFWS is a promising, non-invasive way to detect heart issues early in patients with lung diseases.
Clinical Trial Registration
Trial numbers: NCT02450968 and NCT03173508.
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