Study on PEG-rhG-CSF for Preventing Neutropenia in Nasopharyngeal Carcinoma
Background
This study examines how effective and safe Polyethylene glycolated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) is in preventing neutropenia during concurrent chemoradiotherapy for nasopharyngeal carcinoma (NPC).
Methods
Conducted from June 1, 2021, to October 31, 2022, this single-center study involved patients with locally advanced NPC. Participants were split into two groups:
- Experimental Group: Received PEG-rhG-CSF injections after chemotherapy cycles.
- Control Group: Received standard care without additional treatment.
Key outcomes measured included:
- Incidence of grade 3/4 neutropenia
- Blood cell count changes
- Rates of febrile neutropenia
- Delays or interruptions in chemotherapy/radiotherapy
- Incidents of oral mucositis and bone pain
Results
- The experimental group had a lower incidence of grade 3 neutropenia (P = 0.026).
- Higher white blood cell and neutrophil counts were observed in the experimental group (P < 0.01).
- Delays in chemotherapy were significantly lower in the experimental group (2.3% vs. 29.5%, P = 0.001).
- Radiotherapy interruptions were also lower in the experimental group (2.3% vs. 27.3%, P = 0.003).
- 34.1% of patients in the experimental group experienced mild bone pain, with no severe cases reported.
Conclusions
Using PEG-rhG-CSF helps reduce neutropenia in patients undergoing concurrent chemoradiotherapy for NPC. This leads to fewer delays and interruptions in treatment, with manageable side effects.
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