Neurodevelopmental Outcomes After Nitric Oxide During Cardiopulmonary Bypass for Open Heart Surgery
Study Overview
This study looked at how adding nitric oxide (NO) during heart surgery affects the brain development of infants with congenital heart defects. The goal was to see if NO could help reduce inflammation and improve recovery.
Key Details
- Participants: 1364 infants under 2 years old who had open heart surgery.
- Groups: One group received NO during surgery, while the other received standard care.
- Follow-Up: 12 months after surgery to assess development and quality of life.
Main Findings
After 12 months, there was no significant difference in brain development scores between the NO group and the standard care group. Factors like prematurity and longer hospital stays were linked to lower development scores.
Conclusions
Using NO during surgery did not improve brain development or quality of life for infants after 12 months. Future studies should focus on higher-risk patients and explore different treatment options.
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